REVIEW article
Front. Aging Neurosci.
Sec. Cellular and Molecular Mechanisms of Brain-aging
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1575204
Adenosine diphosphate-ribosylation greatly affects proteins function:a focus on neurodegenerative diseases
Provisionally accepted
Chaowen Huang1Huilin Xiao2Yang Yang3Jiankun Luo2Yixi Lai2Shizhen Liu2
Kanmin Mao4*
Jialong Chen2*Liling Wang3*- 1Department of Respiratory Medicine, Jiangmen Central Hospital Affiliated Jiangmen Hospital of Sun Yat-Sen University, Jiangmen, China
- 2School of Public Health, Guangdong Medical University, Dongguan, China
- 3Rehabilitation department, Affiliated Shenzhen Baoan Central Hospital Group of Guangdong Medical University, Shenzhen, China
- 4Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Adenosine diphosphate-ribosylation (ADPRylation) is a reversible posttranslational modification that plays a crucial role in cellular homeostasis and disease development. ADPRylation is produced via nicotinamide adenine dinucleotide hydrolysis and modifies proteins via corresponding transferases, mainly poly(ADP-ribose) polymerases (PARPs), the inhibitors of which have been used in the clinical treatment of cancer. ADPRylation is involved in various physiological processes, including pathogen infection, inflammation, DNA repair, and neurological disorders. In neurodegenerative diseases (NDs), dysregulated ADPRylation contributes to protein aggregation, neuroinflammation, and metabolic disturbances, while targeted modulation shows therapeutic potential. ADPRylation differentially regulates neurodegenerative processes, and PARP inhibitors can reduce neuroinflammation, oxidative stress, and metabolic dysfunction. However, challenges such as poor blood-brain barrier penetration and cell type-specific responses limit clinical translation. This review summarizes recent findings on the role of ADPRylation and PARPs in NDs, highlighting their involvement in protein aggregation and cellular signaling. It emphasizes the importance of ADPRylation in neuronal cells and supports the development of precision therapies targeting this pathway to address current treatment challenges in NDs.
Keywords: Adenosine diphosphate-ribosylation1, Neurodegenerative diseases2, proteins function3, PARP4, post-translational modification5
Received: 13 Feb 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Huang, Xiao, Yang, Luo, Lai, Liu, Mao, Chen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kanmin Mao, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Jialong Chen, School of Public Health, Guangdong Medical University, Dongguan, China
Liling Wang, Rehabilitation department, Affiliated Shenzhen Baoan Central Hospital Group of Guangdong Medical University, Shenzhen, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.