Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease：An Update

Zhou Bingyuan^1*Jing Li^1,2Anqi Wu¹Xuewei Wang¹Cheng Le¹Gaoshang Yang¹Dahong Gao^2*Caifeng Zhu^2*

• ¹Anhui University of Chinese Medicine, Hefei, China
• ²Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui Province, China

Ferroptosis is a newly discovered form of programmed cell death, primarily caused by an imbalance between iron-dependent oxidative damage and antioxidant defense mechanisms within the cell. It differs from previously reported forms of cell death, such as apoptosis, necrosis, and autophagy, in terms of morphology, biochemistry, and genetics. Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by pathological features including neurofibrillary tangles (NFTs), senile plaques (SPs), and abnormal iron deposition, suggesting that ferroptosis may be involved in its disease progression.Although recent studies have made significant progress, the mechanisms underlying neuronal ferroptosis in AD remain incompletely understood. This review, based on elucidating the process and regulatory mechanisms of cellular ferroptosis, explores and supplements the correlation between iron overload and redox imbalance with the main pathological mechanisms of AD, providing new insights for the treatment of AD and the development of new drugs.