ORIGINAL RESEARCH article
Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1590783
This article is part of the Research TopicUnlocking Potential: Cognitive Rehabilitation for Individuals with Acquired Brain InjuriesView all 7 articles
Effectiveness of Computer-Assisted Cognitive Training on Cognitive Function and Activities of Daily Living in Patients with Post-stroke Cognitive Impairment
Provisionally accepted
- 1Haining Central Hospital, Haining, China
- 2Second Hospital of Jiaxing City, Jiaxing, China
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Objective: To investigate the effects of computer-assisted cognitive training (CACT) on cognitive function and activities of daily living in patients with post-stroke cognitive impairment. Additionally, it sought to explore the changes in specific cognitive domains before and after treatment. Design: A double-blind, randomized, controlled trial. Setting: Rehabilitation wards or outpatient clinics. Participants: Sixty patients with post-stroke cognitive impairment. Interventions: Participants were randomly assigned to either the control (n=30) or intervention group (n=30). Both groups received conventional rehabilitation and cognitive training, and the intervention group additionally receiving CACT. Main Outcome Measures: The primary outcome measures included the Mini-Mental State Examination (MMSE) and event-related potential (ERP) P300 for cognitive function, the modified Barthel Index (MBI) for activities of daily living. Secondary outcomes were the Trail Making Test (TMT), the Symbol-Digit Modalities Test (SDMT), the Auditory Verb Learning Test-Huashan version (AVLT-H), the Boston Naming Test (BNT), and the Clock Drawing Test (CDT), which assessed cognitive function across specific domains.Result: Both groups showed significant improvements in MMSE, MBI, P300 amplitude, and P300 latency, with the intervention group demonstrating more pronounced improvements compared to the control group. In terms of specific cognitive domains, the intervention group exhibited greater improvements than the control group in the TMT-A, TMT-B, and AVLT-H. Both groups showed improvements in SDMT and BNT, but the differences between the groups were not statistically significant. Additionally, there was no significant improvement in the CDT for either group before and after treatment. Conclusion: CACT was found to improve patients' cognitive function, especially in terms of attention, executive function, and memory. It can also effectively improve activities of daily living.
Keywords: Computer-assisted cognitive training, Stroke, cognitive impairment, Attention, execution, Memory Funding: Science and Techology Bureau of Jiaxing City(2023AD31033)
Received: 10 Mar 2025; Accepted: 30 Jul 2025.
Copyright: © 2025 Feng, Sun, Liu, Li, Yao, Fu and XD. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jia Liu, Second Hospital of Jiaxing City, Jiaxing, China
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