ORIGINAL RESEARCH article

Front. Aging Neurosci.

Sec. Alzheimer's Disease and Related Dementias

Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1599402

a-klotho as a biomarker of amyloid b levels in the cerebrospinal fluid

Provisionally accepted
Jacob RaberJacob Raber1*Alexandra PedersonAlexandra Pederson2Emily BunnellEmily Bunnell2Nora MattekNora Mattek2Nora GrayNora Gray2Steven G. KohamaSteven G. Kohama2Alison R WeissAlison R Weiss2Joseph QuinnJoseph Quinn2Henryk F UrbanskiHenryk F Urbanski2
  • 1Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, United States
  • 2Oregon Health and Science University, Portland, Oregon, United States

The final, formatted version of the article will be published soon.

Select one of your emails

You have multiple emails registered with Frontiers:

Notify me on publication

Please enter your email address:

If you already have an account, please login

You don't have a Frontiers account ? You can register here

CSF a-klotho levels might affect Ab40, Aβ42, and the Ab42/40 ratio in the cerebrospinal fluid (CSF). CSF a-klotho was assayed in ovariectomized rhesus macaques (NHPs) maintained on a Western-style diet (WSD) to assess the effect of estrogen hormone therapy (HT). CSF and serum aklotho was also analyzed in females and males of different ages and whether it was associated with Ab42, Ab40, or the Ab42/40 ratio. Furthermore, CSF and serum a-klotho were analyzed in women and men with dementia and controls and whether they were associated with CSF Ab levels. HT was associated with increased CSF a-klotho levels. Furthermore, a-klotho and Ab levels were correlated in a species-and cognitive health-dependent fashion. Higher CSF and serum levels of a-klotho were seen in controls than in patients with dementia. Understanding the species differences in the beneficial effects of a-klotho on CSF Ab physiology should open new avenues for treating AD.

Keywords: a-klotho, APOE, ab, CSF, Serum, rhesus macaques, cognitive healthy elderly, Dementia

Received: 24 Mar 2025; Accepted: 29 May 2025.

Copyright: © 2025 Raber, Pederson, Bunnell, Mattek, Gray, Kohama, Weiss, Quinn and Urbanski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Jacob Raber, Behavioral Neuroscience, Oregon Health and Science University, Portland, 97239, Oregon, United States

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material