REVIEW article
Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1599773
Necroptosis in Vascular Cognitive Impairment: Mechanisms and Therapeutic Potential
Provisionally accepted
- 1Department of Pathology, Jiujiang University affiliated Hospital, Jiujiang, Hebei Province, China
- 2Department of Neurology, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi Province, China
- 3Jiujiang University Affiliated Hospital, Jiujiang, China
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Cerebral ischemia and hypoxia play key roles in the occurrence and development of vascular cognitive impairment (VCI). However, the pathophysiology of VCI remains unclear. Necroptosis is a non-cysteine-dependent form of cell death mediated by serine/threonine kinases receptor-interacting protein kinase-1 and -3 and mixed lineage kinase domain-like protein. A search of PubMed and Web of Science was conducted using terms related to VCI and necroptosis. Necroptosis is important in neuroinflammation, neuronal loss, blood-brain barrier dysfunction, and demyelination.Cerebral ischemia activates the necroptotic pathway, and necroptosis inhibitors have a significant inhibitory effect on brain injury. This review focuses on the pathogenesis of VCI and clarifies the core regulatory mechanism of necroptosis in vascular dementia, which lays a scientific foundation for cognitive impairment prevention and treatment by targeting necroptosis in VCI.
Keywords: SW: Writing -original draft, investigation, Software, visualization, Writing -review & editing. LC: Funding acquisition, Writing -original draft, Writing -review & editing. CS: Data curation, Writing -review & editing. LW: Data curation
Received: 25 Mar 2025; Accepted: 10 Jun 2025.
Copyright: © 2025 Wei, chen, shen, li, teng, wang and zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: xiaorong zhang, Jiujiang University Affiliated Hospital, Jiujiang, China
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