ORIGINAL RESEARCH article
Front. Aging Neurosci.
Sec. Neuroinflammation and Neuropathy
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1607332
This article is part of the Research TopicStroke Research in the Elderly: Addressing Ageism and PrognosticationView all 12 articles
Relationship between the platelet-to-lymphocyte ratio and in-hospital mortality of ischemic stroke patients in the intensive care unit
Provisionally accepted
- 1Department of Pharmacy, The Affiliated Hospital of Jinggangshan University, Ji'an, China
- 2Baoying People's Hospital, Jiangsu, China
- 3The Affiliated Hospital of Jinggangshan University, Ji'an, China
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The relationship between the platelet-to-lymphocyte ratio (PLR) and the prognosis of patients with ischemic stroke was unclear.Objective This study aimed to explore the correlation between PLR levels and in-hospital mortality in ischemic stroke patients admitted to the intensive care unit (ICU).Methods A retrospective cohort study was conducted using data from the MIMIC-IV database. Demographic and clinical data of all participants were collected, and the study outcome was in-hospital mortality. Patients were divided into three groups based on the tertiles of PLR: low PLR group (PLR < 0.88), intermediate PLR group (0.88 ≤ PLR < 1.73), and high PLR group (PLR ≥ 1.73).Multivariable-adjusted logistic regression analysis, curve fitting, interaction analysis, and threshold analysis were performed to evaluate the relationship between PLR levels and in-hospital mortality in ischemic stroke patients in the ICU.Results A total of 1,002 critically ill patients with ischemic stroke were included, with an average PLR level of 1.88 ± 2.34. The overall in-hospital mortality rate was 12.48%, with mortality rates of 7.38% in the low PLR group, 8.96% in the intermediate PLR group, and 21.15% in the high PLR group. A non-linear J-shaped relationship was found between PLR and inhospital mortality. The study found that when the PLR value was less than 4.21, there was a positive correlation between PLR and in-hospital mortality. In the subgroup analysis, no statistically significant interactions were found among the subgroups.Conclusion In the ICU setting,PLR levels were independently associated with in-hospital mortality in critically ill patients with ischemic stroke. When PLR was less than 4.21, this emphasized the importance of close monitoring by ICU physicians.
Keywords: platelet-to-lymphocyte ratio, ischemic stroke, In-hospital mortality, Relationship (guanxi), intensive care unit
Received: 07 Apr 2025; Accepted: 24 Jul 2025.
Copyright: © 2025 Liu, Ding, Chen, Chen and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sufang Yang, Department of Pharmacy, The Affiliated Hospital of Jinggangshan University, Ji'an, China
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