REVIEW article
Front. Aging Neurosci.
Sec. Cellular and Molecular Mechanisms of Brain-aging
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1627921
Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases
Provisionally accepted
RAVINDRAN JAGANATHAN1
Ashok Iyaswamy2,3*
SENTHILKUMAR KRISHNAMOORTHI2
Abhimanyu Thakur4
Siva Sundara Kumar Durairajan5
Chuanbin Yang6*Dapkupar Wankhar7*- 1Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Malaysia
- 2School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, SAR China
- 3Karpagam Academy of Higher Education, Coimbatore, India
- 4Ben May Department for Cancer Research, The University of Chicago, Chicago, United States
- 5Central University of Tamil Nadu, Thiruvarur, India
- 6The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China
- 7Assam down town University, Guwahati, India
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Aging is a normal process causing deteriorations deterioration in normal brain function and is inevitable. The aging process is described by the buildup of senescent cells and a decline in the ability to maintain essential homeostatic functions. Cellular aging represents a critical process where cells undergo cell cycle arrest in reaction response to stress and neuronal damage. Many neurodegenerative disorders are closely linked tohighly correlated with cellular senescence caused by oxidative stress, ROS generation, and DNA damage. Therefore, there is a need to targeting cellular senescence is essential for the therapy of neurodegenerative disorders. This review outlines the understanding of cellular senescence, its role in the aging process, signalling pathways, autophagy, lysosomal biogenesis, and its contribution to various neurodegenerative disorders. In addition, we will conclusively address the possibility of senolytic drugs, notably phytochemicals such as dasatinib, quercetin, and fisetin, as a therapeutic approach to target senescent cells and improve outcomes in neurodegenerative illnesses. This review will encourage the researchers to identify novel compounds or phytochemicals that might could be used as senolytic drugs for treating manynumerous neurodegenerative diseases.
Keywords: cellular senescence, Senolytic drugs, Neurodegenerative Diseases, Aging, DNA Damage
Received: 13 May 2025; Accepted: 08 Sep 2025.
Copyright: © 2025 JAGANATHAN, Iyaswamy, KRISHNAMOORTHI, Thakur, Durairajan, Yang and Wankhar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ashok Iyaswamy, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, SAR China
Chuanbin Yang, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China
Dapkupar Wankhar, Assam down town University, Guwahati, India
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.