REVIEW article
Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1632365
Exercise-Mediated Cerebrovascular Repair in Alzheimer's Disease: From Pathophysiology to Therapeutic Precision
Provisionally accepted
- 1Central Lab, Shanghai Pudong New Area People's Hospital, Pudong, China
- 2Shanghai University of Medicine and Health Sciences, Shanghai, China
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Cerebrovascular dysfunctions, encompassing changes in cerebrovascular microstructure, blood-brain barrier (BBB) integrity, cerebrovascular reactivity, and cerebral blood flow (CBF), accelerate the pathological progression of Alzheimer's disease (AD). Exercise emerges as a promising non-pharmacological intervention that enhances cerebrovascular repair for the treatment of AD. This review summarizes the pathological vascular changes in AD pathology, such as pericyte loss, endothelial dysfunction, and capillary fibrosis, which exacerbate hypoperfusion, hypoxia, and amyloidogenesis. We further discuss the contributing vascular factors and underlying signaling mechanisms to explore potential targets for AD diagnosis and therapy. Finally, we present evidence concerning the impact of exercise on cerebral vascular signaling and the cells involved in vascular plasticity. We also address the impact of various exercise patterns on cerebrovascular health. This work aims to uncover the potential and intervention effects of exercise on cerebrovascular nonmalignant alterations and will provide exercise strategies for treating AD.
Keywords: Exercise, Alzheimer's disease, Cerebral vessels, vascular function related cells, Vascular factors
Received: 21 May 2025; Accepted: 20 Aug 2025.
Copyright: © 2025 Hu, Cai, Cai, Wei, Zhou, Shu, Wang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jingyun Hu, Central Lab, Shanghai Pudong New Area People's Hospital, Pudong, China
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