REVIEW article
Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1644532
This article is part of the Research TopicThe Role of Neurogenesis in Cognitive Decline During AgingView all 4 articles
The Interaction between Resilience Framework and Neuron-Astrocyte-Synapse Dynamics in AD
Provisionally accepted
- Beijing Tsinghua Changgung Hospital, Beijing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The concept of Resilience can be used to explain why there are differences in the degree to which the brain functions of different individuals are impaired due to aging and pathological factors associated with neurodegenerative diseases. It encompasses cognitive reserve, brain reserve, and brain maintenance. Long-term research has identified a default mode network (DMN) related to cognitive reserve. This mode can modulate the negative impact of Alzheimer's disease (AD) pathological burden on cognitive performance. Meanwhile, the association between neurons and glial cells plays a crucial role in the strength of neural network connections. Glial cells are widely distributed in the brain and interact closely with neurons. Among them, astrocytes are essential for maintaining the normal functions of the central nervous system. In both healthy and diseased states, astrocytes perform a variety of functions, including participating in the regulation of synaptic plasticity, synaptogenesis, maintaining glutamate and ion homeostasis, participating in cholesterol and sphingolipid metabolism, and being able to respond to environmental factors. All of these functions are associated with Alzheimer's disease. In this review, first, we provided an overview of Cognitive Reserve, Brain Maintenance, and Brain Reserve. Then, we expounded on the possible mechanisms of action related to glial cells. Finally, we described their roles in Alzheimer's Disease and therapeutic development. This review may provide information and relevant therapeutic strategies for future research as well as the design of diagnostic and therapeutic interventions.
Keywords: Cognitive Reserve, brain reserve, brain maintenance, Astrocytes, Alzheimer's disease
Received: 10 Jun 2025; Accepted: 27 Aug 2025.
Copyright: © 2025 Ma, Zhao, Feng and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xinhong Feng, Beijing Tsinghua Changgung Hospital, Beijing, China
Fengli Gao, Beijing Tsinghua Changgung Hospital, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.