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ORIGINAL RESEARCH article

Front. Aging Neurosci.

Sec. Neurocognitive Aging and Behavior

Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1656854

This article is part of the Research TopicInsights into Pain Mechanisms – 2024/2025View all articles

Translational Insights into Pain Mechanisms and Balance Impairments in Aging: A Cross-Sectional Study

Provisionally accepted
  • Program of Physical Therapy, Department of Medical Rehabilitation Sciences, King Khalid University, Abha, Saudi Arabia

The final, formatted version of the article will be published soon.

Objectives: This study aimed to investigate the association between pressure pain threshold (PPT), pain intensity, pain catastrophizing, and postural stability and to assess the impact of pain chronicity and duration on functional reach and posturographic outcomes in community-dwelling older adults. Methods: A cross-sectional study was conducted involving 136 older adults (mean age = 74.23 ± 6.52 years). Pain mechanisms were assessed using an algometer (PPT), the Numeric Pain Rating Scale (NPRS), and the Pain Catastrophizing Scale (PCS). Balance was evaluated via force plate posturography (sway metrics) and the Functional Reach Test (FRT). Covariates included Mini-Cog and Geriatric Depression Scale scores. Data were analyzed using Pearson correlations, multiple linear regression, and ANCOVA. Results: Sway velocity was significantly predicted by PPT (B = 0.47, p < 0.001), NPRS (B = – 0.36, p < 0.001), PCS (B = –0.29, p = 0.001), Mini-Cog (B = 0.33, p = 0.003), and GDS (B = – 0.18, p = 0.011), explaining 48% of the variance (R² = 0.48, F(5,130) = 24.15, p < 0.001). Chronic pain was associated with reduced FRT performance (F = 9.45, p = 0.003), and longer pain duration predicted greater sway area (B = 0.014 ± 0.004, p = 0.001). Conclusion: Both sensory and cognitive-affective dimensions of pain, along with pain chronicity, are independently associated with postural stability impairments in older adults. These findings support the integration of multidimensional pain assessments in clinical balance evaluations.

Keywords: postural stability, pain intensity, pressure pain threshold, Pain catastrophizing, Chronic Pain

Received: 07 Jul 2025; Accepted: 03 Oct 2025.

Copyright: © 2025 Alshahrani and REDDY. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Mastour Saeed Alshahrani, msdalshahrani@kku.edu.sa
RAVI SHANKAR REDDY, rshankar@kku.edu.sa

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