SYSTEMATIC REVIEW article
Front. Aging Neurosci.
Sec. Parkinson’s Disease and Aging-related Movement Disorders
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1657349
This article is part of the Research TopicThe role of Inflammasome in Neuroinflammation and NeurodegenerationView all articles
Microglia-associated Research in Parkinson's Disease: A Bibliometric Analysis
Provisionally accepted
- 1Hunan University of Chinese Medicine, Changsha, China
- 2Nanjing University of Chinese Medicine, Nanjing, China
- 3Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China
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Background: Parkinson's disease (PD) is a neurodegenerative disorder that predominantly affects the elderly. Evidence indicates that microglia-mediated neuroinflammation is recognized as one of the key mechanisms in PD. This study aims to analyze the key points, hotspots, and emerging frontiers in research related to PD and microglia. Method: Publications were obtained from the Web of Science and PubMed databases. VOSviewer and CiteSpace were used to generate visual representations and conduct numerical analyses of the dataset. Results: China and the United States were the leading contributors. Shanghai Jiao Tong University was the most active institution. The Journal of Neuroinflammation published the most papers on microglia and PD. Dr. Jau-Shyong Hong was the most prolific author. High-frequency keywords included PD, microglia, neuroinflammation, alpha-synuclein (a-syn), neurodegeneration, microglial activation, and oxidative stress. Gut microbiota and the NLRP3 inflammasome have garnered significant interest from researchers in recent years. Conclusion: This study generated visual mappings of microglia and PD-related research. Neuroinflammation, a-syn, neurodegeneration, microglial activation, and oxidative stress represent major focuses and hotspots in this field. Gut microbiota and the NLRP3 inflammasome have rapidly attracted research attention and are likely to be key directions for future studies in the coming years.
Keywords: Microglia, Parkinson's disease, Neuroinflammation, NLRP3 inflammasome, Gut Microbiota
Received: 01 Jul 2025; Accepted: 02 Sep 2025.
Copyright: © 2025 Chen, Ming Rong, Zhou and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fang Liu, Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China
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