The cerebellar-related cognitive function is sensitive to aging: Implications for early detection

Qianying Ma^1,2*Min Pu³Meijia Li⁴Ling Liu^1*Ruilin Wu^5*

• ¹Beijing Language and Culture University, Beijing, China
• ²Vrije Universiteit Brussel, Brussels, Belgium
• ³Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke, Nuthetal, Germany
• ⁴University of Birmingham, Birmingham, United Kingdom
• ⁵Beihang University, Beijing, China

Background: Accumulating evidence demonstrated that the cerebellum contributes to a wide range of sensorimotor and cognitive functions. However, the relationship between cerebellar function and cognitive abilities in normal aging populations remains unclear. Methods: The present cross-sectional study tested cerebellar-related cognitive changes across middle to late adulthood using the Cerebellar Cognitive Affective Syndrome (CCAS) scale and a perceptual serial reaction time (SRT) task. Participants were divided into three groups: early-middle-aged adults (N = 18, 30–45 years), late-middle-aged adults (N = 19, 46–57 years), and older adults (N = 18, 60–78 years). Results: Although all participants were identified as cognitively healthy by the Mini-Mental State Examination (MMSE), older adults showed significant impairments in the CCAS scale, especially in semantic and phonemic fluency, category switching, digit span backward as well as cube drawing/copy. In the perceptual SRT task, older adults responded slower than their counterparts, reflecting age-related impairments in sensorimotor integration efficiency. However, there were no age-related group differences in learning new procedural knowledge. Importantly, participants with poorer CCAS performance demonstrated slower response speed and lower accuracy in the perceptual SRT task. Discussion: The current results indicate a dissociation between general cognitive scores screened by MMSE and cerebellar-specific cognitive impairments. Furthermore, as the cerebellum plays a critical role in both sensorimotor and cognitive domains, the current study highlighted the importance of incorporating screening tools sensitive to cerebellar functions in aging research.