PERSPECTIVE article
Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Rethinking the Diagnosis of Primary Progressive Aphasia: Current Challenges and Future Directions
Provisionally accepted
- 1Laval University, Quebec, Canada
- 2Universite Marie et Louis Pasteur, Besançon, France
- 3Centre Hospitalier Universitaire de Quebec-Universite Laval, Québec City, Canada
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Primary Progressive Aphasia (PPA) is a clinical syndrome characterized by the progressive decline of language abilities due to neurodegenerative disease. Accurate and timely diagnosis is critical for effective clinical management, patient support, and research participation. However, several diagnostic challenges persist, including limitations in current syndromic classifications, lack of linguistically and culturally standardized assessment tools, overlap with other neurocognitive disorders, heterogeneity in underlying pathology, limited biomarker specificity, and unequal access to specialized care. This article reviews key diagnostic barriers and proposes future directions to improve the clinical identification and classification of PPA, with an emphasis on cross-linguistic and cross-cultural considerations.
Keywords: primary progressive aphasia, Neurodegenerative Diseases, diagnosis, Language assessment, biomarkers, Cultural considerations
Received: 31 Oct 2025; Accepted: 18 Nov 2025.
Copyright: © 2025 Macoir, Lavoie, Duboisdindien and Laforce. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Joel Macoir, joel.macoir@rea.ulaval.ca
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