EDITORIAL article
Front. Aging Neurosci.
Sec. Neuroinflammation and Neuropathy
This article is part of the Research TopicSex-dependent modulation of neuroinflammation in the aging brainView all 5 articles
Editorial: Sex-Dependent Modulation of Neuroinflammation in the Aging Brain
Provisionally accepted
- 1Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan
- 2National Cheng Kung University Department of Biotechnology and Bioindustry Sciences, Tainan City, Taiwan
- 3Recursion Pharmaceuticals, Salt Lake City, United States
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Neuroinflammation has emerged as a dynamic and multifactorial process that is central to both normal brain aging and the progression of A systems-level framework, combining longitudinal profiling, network biology, and hormonal analysis, will be crucial to unravel how sex, glial cell dynamics, and environmental inputs interact to shape complex neuroinflammatory outcomes. Such mechanistic understanding will guide the design of targeted interventions and preventative strategies tailored to the distinct neurobiological needs of aging men and women.
Keywords: sex differences, Neuroinflammation, Astrocyte-microglia interactions, estrogen signaling, gut-brain axis, Aging and neurodegeneration
Received: 13 Nov 2025; Accepted: 18 Nov 2025.
Copyright: © 2025 Kuo, Tzeng and Fernandez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu-Min Kuo, kuoym@mail.ncku.edu.tw
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