Frontiers in Aging Neuroscience

Original Research

Published on 31 Mar 2025

Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study

in Alzheimer's Disease and Related Dementias

Cassandre Palix
Léa Chauveau
Francesca Felisatti
Anne Chocat
Laurent Coulbault
Oriane Hébert
Florence Mézenge
Brigitte Landeau
Sacha Haudry
Séverine Fauvel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1508677

3,487 views

Original Research

Published on 31 Mar 2025

Serine-129 phosphorylated α-synuclein drives mitochondrial dysfunction and calcium dysregulation in Parkinson’s disease model

in Neurocognitive Aging and Behavior

Jie Jiao
Weijin Liu
Ge Gao
Hui Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1538166

3,976 views
3 citations

Original Research

Published on 28 Mar 2025

Higher dietary butyrate intake is associated with better cognitive function in older adults: evidence from a cross-sectional study

in Alzheimer's Disease and Related Dementias

Jiayu Tu
Jun Zhang
Gang Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1522498

4,937 views
4 citations

Original Research

Published on 28 Mar 2025

Age-related hearing loss associated with cognitive impairment in the Polish cohort of the PURE study

in Neurocognitive Aging and Behavior

Katarzyna Połtyn-Zaradna
Katarzyna Pazdro-Zastawny
Dorota Szcześniak
Alicja Basiak-Rasała
Maria Wołyniec
Katarzyna Zatońska
Tomasz Zatoński

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1540803

2,992 views
1 citation

Original Research

Published on 28 Mar 2025

Neural network localization in Parkinson’s disease with impulse control disorders

in Parkinson’s Disease and Aging-related Movement Disorders

Hucheng Yang
Siyu Gu
Haihua Sun
Fengmei Zhang
Zhenyu Dai
Pinglei Pan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549589

2,367 views
3 citations

Systematic Review

Published on 27 Mar 2025

Effects of boxing exercise in people with Parkinson’s disease: a systematic review

in Parkinson’s Disease and Aging-related Movement Disorders

Zhihai Wang
Baofu Song
Cong Liu
Huihui Ma
Zirong Bai
Marcelo A. S. Carneiro
Layale Youssef
Chao Chen
Lingli Zhang
Dan Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1505326

5,502 views
1 citation

Review

Published on 27 Mar 2025

The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression

in Alzheimer's Disease and Related Dementias

Cong He
Baojiang Chen
Hecai Yang
Xiaoqing Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1554398

5,995 views
6 citations

Original Research

Published on 27 Mar 2025

The multiple mediating roles of depression and grandchild care in the relationship between social participation and cognitive function among middle-aged and elderly Chinese: an empirical study based on CHARLS 2020 data

in Neurocognitive Aging and Behavior

Sumei Zhou
Tianfang Deng
Shirong Shao
Zhi Zeng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549615

5,022 views
1 citation

Original Research

Published on 27 Mar 2025

Astrocytes-associated research in Parkinson’s disease: an explored trends analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Yan-Jun Chen
Ming-Rong Xie
Sheng-Qiang Zhou
Fang Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1563142

3,059 views
2 citations

Original Research

Published on 27 Mar 2025

Interaction and overall effects of underweight, low muscle mass, malnutrition, and inflammation on early-onset mild cognitive impairment in type 2 diabetes

in Neurocognitive Aging and Behavior

Chen-Ying Lin
Ya-Jie Zhai
Fan Wu
Hao-Hua An
Tong Chen
Hui-Na Qiu
Jing-Bo Li
Jing-Na Lin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1498478

4,637 views

Editorial

Published on 27 Mar 2025

Editorial: Targeting the aging mitochondria: mechanisms, methods, and therapeutic strategies

in Cellular and Molecular Mechanisms of Brain-aging

Zhiquan Li
Konstantinos Palikaras
Yuan Li
Vilhelm A. Bohr

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1591288

2,660 views
1 citation

Original Research

Published on 26 Mar 2025

Assessing diagnostic performance of plasma biomarkers in Alzheimer’s disease versus cognitively unimpaired individuals: P-tau217 emerges as the optimal marker in Chinese cohorts

in Alzheimer's Disease and Related Dementias

Shinan Wang
Dequan Liu
Haiyan Li
Xiaodong Jia
Hailan Zhou
Wenying Yu
Tong Li
Liping Pan
Baorong Chen
Yujia Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1554805

3,744 views

Brief Research Report

Published on 26 Mar 2025

From genes to drugs: targeting Alzheimer’s with circadian insights

in Alzheimer's Disease and Related Dementias

Zekun Li
Xiaohan Li
Lei Su
Zibo Zhang
Hongmin Guo
Yihao Ge
Fang Dong
Feng Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1527636

2,806 views

Perspective

Published on 25 Mar 2025

Targeting neuroplasticity: a viewpoint on a future research direction with Parkinson’s disease-related fatigue

in Parkinson’s Disease and Aging-related Movement Disorders

Shijie Hao
Jianpeng Zou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1503296

2,964 views

Original Research

Published on 25 Mar 2025

Whole-brain 3D imaging of dopaminergic neurons and glial cells in the mouse model of Parkinson’s disease induced by 6-OHDA

in Parkinson’s Disease and Aging-related Movement Disorders

Mengqi Wang
Linglong Xiao
Yifeng Shi
Yaping Wu
Xinyuejia Huang
Yang Wu
Yangyang Xu
Lin Bai
Wei Pan
Jie Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1503168

3,309 views

Original Research

Published on 25 Mar 2025

β2-microglobulin and cognitive decline: unraveling the mediating role of the Dunedin Pace of Aging methylation

in Neurocognitive Aging and Behavior

Yujun Ke
Ping Chen
Chunlan Wu
Qinqin Wang
Kai Zeng
Min Liang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1505185

2,631 views