REVIEW article
Front. Aging
Sec. Healthy Longevity
Volume 6 - 2025 | doi: 10.3389/fragi.2025.1452917
This article is part of the Research TopicNutritional Strategies Towards Healthy Aging and LongevityView all 3 articles
The Gut Microbiota and Aging: Interactions, Implications, and Interventions
Provisionally accepted
Despoina Gyriki1
Christos G. Nikolaidis2
Eugenia Bezirtzoglou1
Chrysa Voidarou1
Elisavet Stavropoulou1*
CHRISTINA TSIGALOU1*- 1Democritus University of Thrace, Komotini, Greece
- 2Vostaneio-General Hospital of Mytilene, Mytilene, Greece
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The human microbiota, a complex ecosystem of microorganisms inhabiting various body sites,particularly the gut, plays a crucial role in maintaining health and influencing disease susceptibility.Dysbiosis, characterized by alterations in microbial composition and diversity, has been implicated in numerous diseases, including those associated with aging. This review examines the complexrelationship between gut microbiota and aging, highlighting the age-associated gut microbiota alterations, the factors contributing to these changes, the links between microbiota and age-related diseases, and the potential of interventions targeting the microbiome to extend lifespan and improve health outcomes in the elderly. Further research is needed to unravel the intricate mechanisms underlying the interplay between the microbiome and aging, paving the way for innovative strategies to promote healthy aging.
Keywords: Gut Microbiota, gut microbiome, Dysbiosis, Aging, age-related diseases, Longevity, Probiotics, Diet
Received: 21 Jun 2024; Accepted: 25 Apr 2025.
Copyright: © 2025 Gyriki, Nikolaidis, Bezirtzoglou, Voidarou, Stavropoulou and TSIGALOU. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Elisavet Stavropoulou, Democritus University of Thrace, Komotini, Greece
CHRISTINA TSIGALOU, Democritus University of Thrace, Komotini, Greece
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