Frontiers in Aging

Original Research

Published on 26 Feb 2026

Ectoine attenuates H2O2-Induced cellular senescence in human keratinocytes and endothelial cells by modulating the p53/p21 and p16 pathways

in Cellular Senescence

Meini Li
Jingyue Zhang
Wenke Yang
Zengqiang Miao
Yanran Pai
Yi Yi
Jie Shuang
Xiang Gao
Yongzhen Li

Frontiers in Aging

doi 10.3389/fragi.2026.1754569

128 views

Original Research

Published on 26 Feb 2026

Development and validation of a machine learning-based risk prediction model for sarcopenia in community hospital patients: a retrospective cohort study

in Musculoskeletal Aging

Xue Zhao
Wang Yao
Jiawei Shen
Xinyu Tang
Jue Zheng
Chang Guo
Sun Ye
Miqiong Li
Chao Wang
Peihao Yin

Frontiers in Aging

doi 10.3389/fragi.2026.1772792

Original Research

Published on 26 Feb 2026

Emerging PFAS contaminants PFNA and PFSA amplify epigenetic aging: sex- and age-stratified risks in an aging population

in Genetics, Genomics and Epigenomics of Aging

Ya-Qian Xu
Chongyu Ding
Hui Zhang
Yulu Gong
Darong Hao
Xuetong Zhao
Kai Li
Xiangwei Li

Frontiers in Aging

doi 10.3389/fragi.2025.1722675

993 views

Editorial

Published on 25 Feb 2026

Editorial: Unraveling the complexities of premature aging: mechanisms and interventions

in Aging and the Immune System

Mayank Choubey
Shivani Srivastava
Vinay Kumar

Frontiers in Aging

doi 10.3389/fragi.2026.1812422

Original Research

Published on 25 Feb 2026

Elevated circulating GDF11 and its role in age-related sarcopenia: insights from clinical, transcriptomic, and in vitro analyses

in Musculoskeletal Aging

Rui Chen
Xin Dai
Hong Wang
Ting Zhang
Zhao Zhang
Yaoxia Liu
Zhen Fan

Frontiers in Aging

doi 10.3389/fragi.2026.1736069

Systematic Review

Published on 25 Feb 2026

Effect of milk and dairy intake on cognitive function in older adults: a systematic review and meta-analysis

in Interventions in Aging

Yessica Giraldo-Castrillon
Juan Diego Mendoza
Marianne Lopez-Cabrera
Jose P. Lopez-Lopez
Patricio Lopez-Jaramillo

Frontiers in Aging

doi 10.3389/fragi.2026.1709281

301 views

Original Research

Published on 25 Feb 2026

Use of sensing technologies to assess sleep quality and physical activity levels in nursing home residents with dementia taking nightly psychotropic drugs for sleep disturbance: a cross-sectional study

in Interventions in Aging

Lydia D. Boyle
Brice Marty
Kristoffer Haugarvoll
Ole Martin Steihaug
Bettina S. Husebo

Frontiers in Aging

doi 10.3389/fragi.2026.1768935

132 views

Editorial

Published on 25 Feb 2026

Editorial: Insights in genetics, genomics and epigenomics of aging: 2025

in Genetics, Genomics and Epigenomics of Aging

Marcella Reale

Frontiers in Aging

doi 10.3389/fragi.2026.1786864

756 views

Review

Published on 24 Feb 2026

Preventing ovarian aging: from redox-targeted strategies to extracellular vesicle-based therapies

in Aging, Metabolism and Redox Biology

Chiara Camerano Spelta Rapini
Camila Cecilia Rojo-Fleming
Chiara Di Berardino
Alessia Peserico
Giulia Capacchietti
Umberto Tosi
Nicola Bernabò
Mauro Mattioli
Barbara Barboni

Frontiers in Aging

doi 10.3389/fragi.2026.1707614

Review

Published on 24 Feb 2026

The tight bond between Fanconi anemia and aging

in Genetics, Genomics and Epigenomics of Aging

Marco Antonio Mejía-Barrera
Enya Enara Martínez-Torres
Ulises Juárez-Figueroa
Leda Torres
Moisés O. Fiesco-Roa
Benilde García-de-Teresa
Juan Carlos Gomez-Verjan
Jorge Meléndez-Zajgla
Alfredo Rodríguez
Silvia Sánchez

Frontiers in Aging

doi 10.3389/fragi.2026.1752160

428 views

Original Research

Published on 24 Feb 2026

Effects of physical disability and widowhood on the survival of centenarians: a 7-year follow-up of CHCCS centenarians

in Healthy Longevity

Songmei Han
Dongxu Zhao
Jianbo Wu
Mingzhi Shen
Fei Hua

Frontiers in Aging

doi 10.3389/fragi.2026.1764198

126 views

Original Research

Accepted on 23 Feb 2026

The association of maximal plantar flexion and dorsiflexion strength on static and dynamic balance as well as gait velocity in the elderly

in Musculoskeletal Aging

Konstantin Warneke
Andreas Stotz
Andreas Konrad
Astrid Zech

Frontiers in Aging

Original Research

Accepted on 23 Feb 2026

Metabolite biomarkers present in urine predict alterations in skeletal muscle associated with sarcopenia

in Musculoskeletal Aging

Rafaela Andrade-Vieira
Hirad A. Feridooni
Alyne Teixeira
Dylan Alexander Deska-Gauthier
Xingjian Chang
Tobias Karakach
Rebecca Moyer
John Paul Frampton

Frontiers in Aging

Original Research

Accepted on 23 Feb 2026

PCKP versus UPKP for Moderate-to-Severe Osteoporotic Vertebral Compression Fractures: A Prospective Randomized Controlled Trial Revealing Synergistic Mechanisms of Optimized Bone Cement Distribution and Anti-Osteoporosis Therapy on Medium-to Long-Term Outcomes

in Musculoskeletal Aging

FuGuo Yang

Frontiers in Aging

137 views

Systematic Review

Published on 23 Feb 2026

Non-pharmacological mental health interventions for older adults in Mexico: a systematic review

in Interventions in Aging

María Fernanda Zapata-De la Rosa
Harvey Apolonio-Cortés
Rodrigo Ramirez-Rodriguez
Rafael Fernández-Demeneghi
Yuliana Yessy Gomez Rutti
Fabiola Ortiz-Cruz
Angel Puig-Lagunes

Frontiers in Aging

doi 10.3389/fragi.2026.1730672

795 views

Original Research

Published on 19 Feb 2026

Reduction of calreticulin and ERp57 with age reveals the ER stress-related roles in cell viability and organismal lifespan regulation

in Molecular Mechanisms of Aging

Gregor Burdeos
Sophie Neuber-Schlicht

Frontiers in Aging

doi 10.3389/fragi.2026.1758247

404 views

Brief Research Report

Published on 18 Feb 2026

Obesity and low lean mass are associated with dysregulated IGFBP-3, inflammatory biomarkers, and physical impairment in older adult women with frailty

in Musculoskeletal Aging

Alan L. Fernandes
Rosa M. R. Pereira
Valeria F. Caparbo
Camila S. Figueredo
Caroline F. Gomes
Eduardo F. B. Neto
Diogo S. Domiciano

Frontiers in Aging

doi 10.3389/fragi.2026.1765052

211 views

Original Research

Published on 18 Feb 2026

One-month early time-restricted eating mitigates brain aging and enhances memory in males with metabolic syndrome: an MRI structural study

in Aging, Metabolism and Redox Biology

Yue Qin
Xiaoshi Li
Lei Wang
FengLin Shuang
Xin Jin
Tingting Qu
Yuying Wang
Yunbing Wu
Juan Tian
Yifan Qian

Frontiers in Aging

doi 10.3389/fragi.2026.1752738

281 views

Review

Accepted on 17 Feb 2026

Research Hotspots and Trends in Intrinsic Capacity of Older People in the Context of Population Aging based on CiteSpace

in Interventions in Aging

Minhua Ren
Hongtao Guo
Ye Tian
Yingjie Guo
Wanjun Guo
Liangjin Zhu

Frontiers in Aging

Original Research

Accepted on 17 Feb 2026

Evaluating the Performance of Large Language Models in Sarcopenia-Related Patient Queries: A Foundational Assessment for Patient-Centered Validation

in Musculoskeletal Aging

Tao HUANG
Ben Kirk
Jacqueline CLOSE
Jae-Young Lim
Gustavo Duque
Peter Ebeling
Minghui Yang
Maoyi Tian
Chun Sing CHUI
Chaoran LIU

Frontiers in Aging

Original Research

Accepted on 17 Feb 2026

A New Physical Measure for Sarcopenia assessment: Development Validation and Physiological Evaluation

in Musculoskeletal Aging

Blanca Pedauyé Rueda
José Luis Maté Muñoz
Juan Hernández Lougedo
Iñigo Aparicio García
Sara Cerrolaza-Tudanca
Mauel Rozalén Bustín
Inmaculida Rodríguez Moreno
Pablo García Fernández

Frontiers in Aging

Original Research

Accepted on 17 Feb 2026

First Metagenomic Analysis of Age-Associated Changes in the Gut Microbiome Among Healthy Saudi Adults: SAMS Pilot Study

in Healthy Longevity

Roua Almatrafi
Abdulrahman Alasiri
Ghaida Almuneef
Amal A Al-Hazzani
Majed F. Alghoribi
Maymounah Hakami
Assad Arafah
Raniah Saleem Alotibi
Shatha Alrabiah
Nasser Alqurainy

Frontiers in Aging

Original Research

Accepted on 16 Feb 2026

Anshen Bunao syrup as a potential anti-aging agent: mechanistic insights and pharmacological evidence

in Interventions in Aging

YuanFang Sun
Qi Xia
Ruolan Wu
Gang Liu
Yongkuan Wang
Shikai Yan
Huizi Jin
Xiuyun Zhang
XUE XIAO
Shasha Li

Frontiers in Aging

Review

Accepted on 16 Feb 2026

Wnt16: a new potential therapeutic target for osteoporotic non-vertebral fracture treatment

in Musculoskeletal Aging

Tian Peng Chen
Gongtao Jiang

Frontiers in Aging

688 articles

articles

Ectoine attenuates H2O2-Induced cellular senescence in human keratinocytes and endothelial cells by modulating the p53/p21 and p16 pathways

Development and validation of a machine learning-based risk prediction model for sarcopenia in community hospital patients: a retrospective cohort study

Emerging PFAS contaminants PFNA and PFSA amplify epigenetic aging: sex- and age-stratified risks in an aging population

Editorial: Unraveling the complexities of premature aging: mechanisms and interventions

Elevated circulating GDF11 and its role in age-related sarcopenia: insights from clinical, transcriptomic, and in vitro analyses

Effect of milk and dairy intake on cognitive function in older adults: a systematic review and meta-analysis

Use of sensing technologies to assess sleep quality and physical activity levels in nursing home residents with dementia taking nightly psychotropic drugs for sleep disturbance: a cross-sectional study

Editorial: Insights in genetics, genomics and epigenomics of aging: 2025

Preventing ovarian aging: from redox-targeted strategies to extracellular vesicle-based therapies

The tight bond between Fanconi anemia and aging

Effects of physical disability and widowhood on the survival of centenarians: a 7-year follow-up of CHCCS centenarians

The association of maximal plantar flexion and dorsiflexion strength on static and dynamic balance as well as gait velocity in the elderly

Metabolite biomarkers present in urine predict alterations in skeletal muscle associated with sarcopenia

PCKP versus UPKP for Moderate-to-Severe Osteoporotic Vertebral Compression Fractures: A Prospective Randomized Controlled Trial Revealing Synergistic Mechanisms of Optimized Bone Cement Distribution and Anti-Osteoporosis Therapy on Medium-to Long-Term Outcomes

Non-pharmacological mental health interventions for older adults in Mexico: a systematic review

Reduction of calreticulin and ERp57 with age reveals the ER stress-related roles in cell viability and organismal lifespan regulation

Obesity and low lean mass are associated with dysregulated IGFBP-3, inflammatory biomarkers, and physical impairment in older adult women with frailty

One-month early time-restricted eating mitigates brain aging and enhances memory in males with metabolic syndrome: an MRI structural study

Research Hotspots and Trends in Intrinsic Capacity of Older People in the Context of Population Aging based on CiteSpace

Evaluating the Performance of Large Language Models in Sarcopenia-Related Patient Queries: A Foundational Assessment for Patient-Centered Validation

A New Physical Measure for Sarcopenia assessment: Development Validation and Physiological Evaluation

First Metagenomic Analysis of Age-Associated Changes in the Gut Microbiome Among Healthy Saudi Adults: SAMS Pilot Study

Anshen Bunao syrup as a potential anti-aging agent: mechanistic insights and pharmacological evidence

Wnt16: a new potential therapeutic target for osteoporotic non-vertebral fracture treatment