REVIEW article
Front. Aging
Sec. Healthy Longevity
Volume 6 - 2025 | doi: 10.3389/fragi.2025.1554340
This article is part of the Research TopicSpotlight on Aging: Role of Exercise and Nutrition in Healthy LongevityView all 6 articles
Strength training and Sarcopenia a mandatory link: focus on microRNA
Provisionally accepted
- 1University of Calabria, Cosenza, Italy
- 2Magna Græcia University, Catanzaro, Calabria, Italy
- 3Università telematica San Raffaele, Rome, Lazio, Italy
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Over the last twenty years, increased life expectancy has been observed in both men and women, resulting in a rise in the prevalence of diseases among the elderly population. From this, sarcopenia has an estimated prevalence of 10-16 % of the elderly worldwide. Losing strength and muscle mass in the 65-70 age group represents a significant public health problem. In this review, we emphasize the essential importance of strength training in managing sarcopenia, highlighting the role of microRNAs, small nucleotides that were the subject of last year's Nobel Prize in Physiology or Medicine. These microRNAs regulate protein synthesis and are present in all biological fluids. Some of them are expressed differently by subjects affected by sarcopenia (as happens in various forms of cancer or other diseases). Therefore, monitoring a specific signature of microRNAs can better clarify the etiopathology of sarcopenia, providing an early biomarker for sarcopenia (currently, there are some hypotheses, but none is well recognized), and even serve as the basis for the development of drugs.
Keywords: Sarcopenia, strength training, miRNA, epigenetics, MyomiR, Resistance Training
Received: 01 Jan 2025; Accepted: 08 Jul 2025.
Copyright: © 2025 Cannataro, Abrego-Guandique, Chiari and Cione. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Roberto Cannataro, University of Calabria, Cosenza, Italy
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