ORIGINAL RESEARCH article
Front. Aging
Sec. Healthy Longevity
Volume 6 - 2025 | doi: 10.3389/fragi.2025.1571609
This article is part of the Research TopicInnovative Nutritional Strategies for Cardiovascular Health in Aging PopulationsView all 6 articles
Surrogate insulin resistance indices are associated with left atrial thrombus in patients with nonvalvular atrial fibrillation
Provisionally accepted
- 1Central China Fuwai Hospital, Zhengzhou, China
- 2Henan Provincial Cancer Hospital, Zhengzhou, Henan Province, China
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Atrial fibrillation is the most common cardiac arrhythmia with increased risk of thromboembolic events. Surrogate insulin resistance indices, triglyceride glucose (TyG) index and triglyceride glucose-body mass index (TyG-BMI index), are predictors of adverse outcomes in patients with cardiovascular diseases. In this study, we aimed to determine the association between insulin resistance indices and left atrial thrombus (LAT) in patients with non-valvular atrial fibrillation (NVAF). A total of 466 patients with documented NVAF who underwent transesophageal echocardiography were studied retrospectively. Demographic data, laboratory results, echocardiographic measurements and medication were collected. Logistic regression analysis was performed to determine the association between insulin resistance indices and risk of LAT. C-statistic was calculated to determine the incremental value of insulin resistance indices in predicting LAT compared with CHA2DS2-VASc score. LAT were identified in 46 patients(9.87%). In the full adjustment model, elevated TyG index [per 1 standard deviation(SD) increment; odds ratio(OR):1.588; 95% confidence interval (CI) :1.125-2.241, P=0.009] and TyG-BMI index (per 1 SD increment; OR: 1.570; 95%CI :1.142-2.160, P=0.005) were significantly associated with high risk of LAT. Compared to the lowest quartile, ORs for the highest quartile were 3.691(95%CI: 1.126-12.096, P=0.031) for TyG index and 10.302(95%CI: 2.232-47.556, P=0.003) for TyG-BMI index. Compared with the CHA2DS2-VASc score alone, insulin resistance indices incorporated into the CHA2DS2-VASc score remain the predictive ability of LAT. The present study suggests that TyG index and TyG-BMI index are new predictors for LAT in patients with NVAF.
Keywords: Triglyceride-glucose index, Triglyceride glucose-body mass index, Insulin Resistance, Left atrial thrombus, Atrial Fibrillation
Received: 05 Feb 2025; Accepted: 31 Jul 2025.
Copyright: © 2025 Zhou, Song, Ma, Wang and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Haixia Fu, Central China Fuwai Hospital, Zhengzhou, China
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