REVIEW article
Front. Aging
Sec. Aging, Metabolism and Redox Biology
Volume 6 - 2025 | doi: 10.3389/fragi.2025.1596050
Advances in the Application of Multi-omics Analysis in Skin Aging
Provisionally accepted
- 1Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- 2Guangdong Medical University, Zhanjiang, Guangdong, China
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Skin aging is a progressive decline in the structural integrity and physiological function of the skin, driven by a complex interplay of intrinsic and extrinsic factors. Consequently, skin aging is classified into intrinsic and extrinsic aging. Intrinsic aging is characterized by epidermal thinning, dryness, fine lines, and reduced elasticity over time, whereas extrinsic aging manifests as epidermal thickening, deep wrinkles, skin laxity, roughness, and pigmentation, particularly in sun-exposed areas, such as the face, neck, and hands. The underlying mechanisms of these two aging processes are intricate and distinct, encompassing various elements, including temporal aspects, genetic predisposition, immune responses, endocrine influences, and ultraviolet radiation. Multi-omics approaches—including macro-genomics, epigenetics, transcriptomics, proteomics, and metabolomics—offer valuable insights into the mechanisms and pathogenesis of skin aging while aiding in the identification of biomarkers and potential therapeutic targets. This review provides an overview of advancements in skin aging research using multi-omics technologies, aiming to foster innovation in research methodologies related to skin aging.
Keywords: Skin Aging, multi-omics, biomarkers, Pathogenesis, anti-aging
Received: 21 Mar 2025; Accepted: 22 Jul 2025.
Copyright: © 2025 Long, Pan, Wu, Nong, Li, Chen and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hong-Wei Guo, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
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