BRIEF RESEARCH REPORT article
Front. Aging
Sec. Aging and the Immune System
Volume 6 - 2025 | doi: 10.3389/fragi.2025.1596565
This article is part of the Research TopicUnraveling Hematopoietic Stem Cell Aging: Pathways and Therapeutic PotentialView all articles
Hematopoietic stem cell size heterogeneity is not linked to changes in stem cell potential of aged HSCs
Provisionally accepted
- University of Ulm, Ulm, Germany
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Aging is associated with a decline in the function of hematopoietic stem cells (HSCs). This decline in HSC function results in reduced hematologic regenerative capacity and an increased incidence of hematologic disorders. In general, aged HSCs show on average an increase in cell size and a lower frequency of cells polar for protein polarity markers. The size of an HSCs has been proposed to be tightly linked to the potential of the HSCs, with small HSCs showing a higher potential compared to large HSCs. The increase in size of HSCs upon aging may be associated with the reduced potential of aged HSCs.HSCs are located within the bone marrow (BM) in distinct microenvironments called niches.These niches provide critical physical and molecular signals that are essential for HSC selfrenewal, proliferation, migration and differentiation. There are multiple types of functional niches, and HSCs within these distinct types of niches show a distinct type of potential.
Keywords: Hematopoietic Stem Cells, Aging, bone marrow niches, Cell size and function, Regenerative potential, Stem cell polarity, stem cell differentiation, hematopoietic aging
Received: 20 Mar 2025; Accepted: 07 May 2025.
Copyright: © 2025 Sacma, Hageb, Zadro, Schuster, Vogel, Eiwen, Sakk and Geiger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mehmet Sacma, University of Ulm, Ulm, Germany
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