ORIGINAL RESEARCH article
Front. Aging
Sec. Aging, Metabolism and Redox Biology
Volume 6 - 2025 | doi: 10.3389/fragi.2025.1618082
This article is part of the Research TopicHarnessing Computational Biology to Unravel Aging Mechanisms and Identify Therapeutic TargetsView all articles
The anti-aging potential of antihypertensive peptides of Pariset, a dataset of algal peptides
Provisionally accepted
ISAAC KARIMI1*
Parisa Olfati1
Layth Jasim Mohammed2Jawad Kadhim Tarrad2Ahmed M Amshawee3Maryam A Hussain4Helgi B Schiöth5*- 1Razi University, Kermanshah, Iran
- 2Babylon university, Babylon, Iraq
- 3University of Hilla, Babylon, Iraq
- 4Al-Furat Al-Awsat Technical University, Kufa, Najaf, Iraq
- 5Uppsala University, Uppsala, Uppsala, Sweden
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Introduction: Cellular senescence drives aging and disease by promoting inflammation and tissue dysfunction. The kidneys, highly susceptible to aging, worsen with hypertension, increasing chronic disease risk. Managing blood pressure with angiotensin-converting enzyme (ACE) inhibitors and natural bioactive peptides helps maintain kidney health. This study explores a kidney-associated aging network and algal peptides with renoprotective and anti-aging effects. Methods: Senescence-associated genes from Human Ageing Genomic Resources (HAGR) were used to construct and analyze a protein-protein interaction (PPI) network, refining a kidney-related subset with angiotensinconverting enzyme (ACE), angiotensin II Receptor Type 1 (AGTR1), and angiotensin II Receptor Type 2 (AGTR2).Algal antihypertensive peptides were filtered out of the laboratory dataset of algal peptides, Pariset, and assessed for allergenicity, antigenicity, toxicity, and anti-aging potential via sequence similarity searches. Selected peptides were prepared for molecular docking, tested against kidney-aging targets, and visualized. Results: A senescence-associated PPI network revealed key aging-related proteins-IL1R, CD4, FN1, STAT3, CD45, APOE, CD44, ITGAM. CD8A, CD68, CDH1, ACE, AGTR1, and AGTR2-linked to inflammation, immunity, and fibrosis. Screening identified 54 antihypertensive peptides, among which seven were predicted to have be non-toxic allergenic and non-antigenic peptides, whileand six out of them exhibited anti-aging properties. KTFPY and others exhibited strong binding to ACE and kidney-aging proteins, suggesting therapeutic benefits. Discussion: The senescence-associated PPI network reveals potentially important aging-related proteins affecting kidney health. Algal peptides, particularly KTFPY, VYRT, PGDTY, PVAFN, and MTFF, exhibit strong ACE binding, suggesting potential antihypertensive and antiaging benefits. CD68 expressed reliable binding affinities with small-molecule ACE inhibitors, and it showedindicated the repurposing potential of these drugs for aging-associated conditions. These computational results highlight the potential of peptide-based therapies in addressing age-related kidney dysfunction, and warranting further experimental investigations.
Keywords: Pariset dataset, algal peptides, Hypertension, Renoprotection, senescence
Received: 25 Apr 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 KARIMI, Olfati, Mohammed, Kadhim Tarrad, Amshawee, Hussain and Schiöth. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
ISAAC KARIMI, Razi University, Kermanshah, Iran
Helgi B Schiöth, Uppsala University, Uppsala, 753 12, Uppsala, Sweden
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.