REVIEW article
Front. Aging
Sec. Aging, Metabolism and Redox Biology
Volume 6 - 2025 | doi: 10.3389/fragi.2025.1635736
Mechanisms of Aging in the Cardiovascular System: Challenges and Opportunities
Provisionally accepted
Xiaoying Zhao1
Xinyue Yang1
Yumeng Lin2
Ruolan Lei3Wei Ding4Xinying He1Ying Cao1
DECHOU ZHANG1
PING LIU1Meirou Liang5
Zhongyu Han2*Yu Jiang1- 1Southwest Medical University, Luzhou, China
- 2Southeast University, Nanjing, China
- 3The First People’s Hospital of Zigong, Zigong, China
- 4Jinzhou Medical University, Jinzhou, China
- 5Shaanxi University of Chinese Medicine, Xianyang, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Cardiovascular diseases (CVDs) pose a significant threat to the health of the elderly population. As the global population ages and medical management remains imperfect, reducing the medical burden of CVDs is of great importance. Aging is a complex process that contributes to the development and progression of CVDs through various mechanisms. The manuscript reviews the mechanisms of aging and their impact on the cardiovascular system. We explore the role of aging in the cardiac microenvironment, highlighting the changes that occur in the heart's cellular and molecular landscape as a result of the aging process.
Keywords: cardiac microenvironment, Aging, cardiac aging, therapy, Inflammation
Received: 27 May 2025; Accepted: 22 Sep 2025.
Copyright: © 2025 Zhao, Yang, Lin, Lei, Ding, He, Cao, ZHANG, LIU, Liang, Han and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhongyu Han, hzyczy1997@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.