REVIEW article
Front. Aging
Sec. Musculoskeletal Aging
Volume 6 - 2025 | doi: 10.3389/fragi.2025.1654711
The Role of Ferroptosis in Osteoporosis: From Pathogenic Mechanisms to Natural Product-Driven Therapeutic Innovations
Provisionally accepted
- Changsha Hospital of Traditional Chinese Medicine Affiliated to Hunan University of Traditional Chinese Medicine, Changsha, China
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Osteoporosis is ,a common bone disease, and it has become a prominent health problem of the elderly in modern society. As a new type of cell death, ferroptosis plays an important role in the occurrence and development of osteoporosis. Therefore, regulation of iron metabolism is helpful for the treatment of osteoporosis. This article not only reviews the molecular mechanism of ferroptosis in osteoporosis, but also focuses on the three-dimensional regulatory network of iron metabolism disorder, lipid peroxidation, and bone homeostasis imbalance. Natural active ingredients with potential inhibiting ferroptosis, including traditional Chinese medicine, and their corresponding targets, are also evaluated from the perspective of natural product chemistry and molecular pharmacology. Finally, the research and development prospects of natural ingredient delivery systems in the treatment of osteoporosis are discussed. Advances in these therapeutic strategies provide new opportunities to address the challenges in the management of osteoporosis and may improve the quality of life of elderly patients. This article comprehensively reviews the related studies of ferroptosis and osteoporosis, providing a valuable reference for research and clinical practice in this field, and contributing to the further development of osteoporosis treatment research.
Keywords: Osteoporosis1, ferroptosis2, lipid peroxidation3, natural active ingredients4, Traditional Chinese Medicine5
Received: 26 Jun 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Zhu, Wu, Peng, He, Hu and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liangyi Xiao, Changsha Hospital of Traditional Chinese Medicine Affiliated to Hunan University of Traditional Chinese Medicine, Changsha, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.