MINI REVIEW article
Front. Aging
Sec. Interventions in Aging
Toward Precision Longevity: Aging Interventions in the Single-Cell Atlas Era
Provisionally accepted
- Baylor College of Medicine, Houston, United States
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With growing global interest in extending not only lifespan but also healthspan, healthy aging has emerged as a central goal in biomedical research. This review provides an overview of current longevity interventions, including genetic manipulations, dietary restriction, exercise, pharmacological treatments, targeting senescence and cellular reprogramming strategies, as studied in key model organisms such as Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus. We examine the limitations and challenges associated with these approaches, particularly their variability across tissues and cell types. Furthermore, we emphasize the critical role of single-cell aging atlas technologies in uncovering cell-type–specific aging patterns and molecular signatures. By integrating single-cell data, we propose that future interventions can be more precisely designed to target aging at the cellular level, thereby enhancing the efficacy and specificity of longevity strategies.
Keywords: Aging, Longevity, anti-aging, pro-longevity interventions, single-cell atlas
Received: 27 Jul 2025; Accepted: 20 Nov 2025.
Copyright: © 2025 Chen, Wang, Gong and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hongjie Li, hongjie.li@bcm.edu
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.