REVIEW article
Front. Aging
Sec. Interventions in Aging
Volume 6 - 2025 | doi: 10.3389/fragi.2025.1693043
This article is part of the Research TopicNutritional Strategies for Enhancing Longevity and Healthy AgingView all 7 articles
Dietary phenolics and exercise complement to delay aging at the source: a comprehensive review spotlighting mitochondrial function
Provisionally accepted
- South China University of Technology, Guangzhou, China
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Background: Aging issues are becoming more prominent, and the aging population is expanding. The reliance on medical or pharmaceutical means of combating aging and disease raises concerns about long-term safety and the economy. Therefore, sustainable and friendly strategies need to be explored urgently. Phenolic-rich antioxidant dietary regimens and exercise integrated into daily habits contain great anti-aging potential. The research on natural laws for anti-aging based on phenolics and exercise is in full swing. Scope and approach: The review first outlines the current status of aging and elucidates the aging root and its causes. Secondly, the anti-aging mechanisms at the source by daily behaviors such as phenolic diets and exercise are introduced. Then, the combined anti-aging strategy of dietary phenolic supplements and exercise is proposed, providing a feasible basis for resource synergy between the two. Finally, constructive comments are made to guide practical implementation and future development. Key findings and conclusions: Mitochondrial dysfunction and its ROS accumulation are the essence of aging pathogenicity, and its causes include lifestyle habits, age, and genes. The precise action on mitochondria through phenolics and exercise to ameliorate their oxidative stress and maintain anti-aging function is in line with contemporary concepts of anti-aging. Although phenolics in combination with exercise for anti-aging are scarce in research and face multiple problems, the new strategy will eventually be adopted as thorny issues are gradually resolved.
Keywords: Aging, Mitochondria, Dietary phenolics, Exercise, combined anti-aging
Received: 26 Aug 2025; Accepted: 20 Oct 2025.
Copyright: © 2025 Zhang, Zhu, Huang and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chuan-He Tang, chtang_scut@163.com
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