MINI REVIEW article
Front. Aging
Sec. Healthy Longevity
This article is part of the Research TopicOne Health in AgingView all 4 articles
Natural Strategies to Optimize Estrogen Levels in Aging Women: Mini Review
Provisionally accepted
- 1Alfaisal University, Riyadh, Saudi Arabia
- 2St Matthew's University, George Town, Cayman Islands
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Introduction: Menopause triggers declining estradiol, causing vasomotor symptoms, bone loss, and urogenital changes. Despite hormone therapy's effectiveness, safety concerns drive 40-50% of Western women toward natural alternatives. Aim: To evaluate evidence supporting non-pharmacological interventions that modulate endogenous estrogen activity in postmenopausal women. Methods: We reviewed literature (2015-2025) examining dietary interventions, micronutrient supplementation, gut microbiome modulation, lifestyle modifications, and botanical remedies for menopausal symptoms. Analysis included randomized controlled trials, systematic reviews, meta-analyses, and cohort studies addressing interventions in peri- and postmenopausal women. Results: Multiple natural approaches demonstrated clinically meaningful effects. Dietary phytoestrogens (50-80 mg/day isoflavones) reduced severe hot flashes by up to 92% and improved metabolic parameters. Flaxseed lignans reduced perimenopausal symptoms. Combined vitamin E and omega-3 lowered hot flush intensity, with vitamin E showing estrogenic receptor activation. Curcumin (500 mg/day) reduced hot flashes and improved metabolic profiles. Probiotics containing L. brevis increased circulating estrogens by up to 26%. Stress reduction improved quality of life, while cognitive behavioral therapy reduced insomnia. Botanicals including black cohosh, red clover, and rhapontic rhubarb reduced vasomotor symptoms, while resveratrol improved bone mineral density. Research gaps remain regarding dosing and genetic variability. Conclusion: A multi-domain approach incorporating phytoestrogen-rich foods, targeted micronutrients, gut microbiome optimization, and regular exercise provides evidence-based options for managing estrogen decline. These approaches offer alternatives for women with contraindications or preferences against pharmaceutical intervention. Future research should focus on personalized approaches incorporating genetic profiling.
Keywords: Estrogens, Phytoestrogens, Micronutrients, Gastrointestinal microbiome, Postmenopause, Life Style, Dietary Supplements
Received: 15 Sep 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 Bolgova, Shypilova and Mavrych. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Volodymyr Mavrych, prof.mavrych@gmail.com
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