MINI REVIEW article
Front. Biomater. Sci.
Sec. Biomaterials Manufacturing and Technology
Volume 4 - 2025 | doi: 10.3389/fbiom.2025.1641339
This article is part of the Research TopicRising Stars in Biomaterials ScienceView all 4 articles
Article Type: Minireview Unlocking the Potential of Stimuli-Responsive Injectable Hydrogels for Bone Healing Applications
Provisionally accepted
- 1Western University, London, Canada
- 2Qatar University, Doha, Qatar
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Stimuli-responsive, or "smart", injectable hydrogels respond to real-time stimuli through physical or chemical changes. This allows hydrogels to be dynamic within their environment in the presence of internal or external stimuli. Owing to this, smart injectable hydrogels have gained noticeable implications within the field of biomedicine. Over the past decade, stimuli-responsive injectable hydrogels have been extensively studied for wound healing and cancer therapies but remain largely unexplored for bone healing applications. In this minireview, we aim to explore the role of smart injectable hydrogels and assess their current and future implications within the field of bone healing. Specifically, we discuss the physicochemical and biological aspects that must be taken into consideration when developing a material in this field, as well as the various strategies for designing such a material. Additionally, we discuss the current role of stimuli-responsive injectable hydrogels for an array of bone healing applications and their potential for successful clinical translation.
Keywords: Stimuli-responsive, Injectable, Hydrogels, bone healing, Biomaterials
Received: 04 Jun 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 Al Mamun, Shamiya, Hasan and Paul. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Arghya Paul, Western University, London, Canada
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