REVIEW article
Front. Biomater. Sci.
Sec. Biomaterials Science for Regenerative Therapies
Volume 4 - 2025 | doi: 10.3389/fbiom.2025.1662900
Advances in Electrical Stimulation for Wound Healing
Provisionally accepted
Hehe Jiang1*
Xiaofei Bi2Xiangchen Chen2Zheng Pang2Bihan Song2Hongxiang Li2Sicheng Feng2Linlin Zhang2Haixiao Hu2- 1School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
- 2Shandong University of Traditional Chinese Medicine, Jinan, China
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Electrical stimulation (ES), as a cutting-edge biomedical strategy for promoting wound healing, accelerates tissue regeneration and repair processes through directional electric field intervention. Research demonstrates that both endogenous weak bioelectric potentials and exogenously applied electric fields can effectively guide cellular migration along electric field gradients while activating the biological activities of fibroblasts, keratinocytes, and endothelial cells. These mechanisms enhance collagen synthesis and accelerate angiogenesis, thereby significantly improving wound closure rates. This review comprehensively examines recent advancements in ES technology for wound healing, focusing on emerging applications of active microcurrent devices, passive microcurrent systems, and electroactive wound dressings. Particular emphasis is placed on innovative applications of conductive polymers (CPs) and nanocomposite materials in wound repair. By systematically analyzing the underlying mechanisms and therapeutic applications of ES in wound healing, this work aims to provide novel perspectives for optimizing ES technologies and facilitating their clinical translation, offering both theoretical significance and practical value in regenerative medicine.
Keywords: electrical stimulation1, wound healing2, Cell proliferation3, angiogenesis4, Therapeutic devices5
Received: 09 Jul 2025; Accepted: 22 Aug 2025.
Copyright: © 2025 Jiang, Bi, Chen, Pang, Song, Li, Feng, Zhang and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hehe Jiang, School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.