REVIEW article
Front. Cell. Neurosci.
Sec. Cellular Neurophysiology
Volume 19 - 2025 | doi: 10.3389/fncel.2025.1556892
Mechanosensitive Piezo1 channel: An emerging target in demyelination disease
Provisionally accepted
- 1Nanchang University, Nanchang, Jiangxi Province, China
- 2Department of Emergency Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, China
- 3Ganzhou People's Hospital, Ganzhou, Jiangxi Province, China
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Many physiological processes in the human body are initiated by mechanical signals, which are transmitted via ion channels. Piezo-type mechanosensitive ion channel component 1 (Piezo1) is a protein highly expressed in the brain, playing a critical role in sensing changes in the mechanical microenvironment. Extensive research has demonstrated that Piezo1 is an essential component for generating currents in mechanically activated cation channels. It is involved in several key processes in the nervous system, including neuronal development and differentiation, nerve regeneration, axon guidance, and myelination. Demyelinating diseases, characterized by the loss of nerve myelin sheaths, occur in the central or peripheral nervous system. These diseases are clinically challenging due to their diverse etiologies, multiple types, poor prognosis, and lack of definitive cures. This article aims to review the current research on the role of Piezo1 in myelination and its involvement in demyelinating diseases, as well as to explore the potential of targeting Piezo1 for therapeutic interventions in such conditions.
Keywords: Piezo1, demyelination, Demyelinating Diseases, Multiple Sclerosis, myelin
Received: 08 Jan 2025; Accepted: 24 Jun 2025.
Copyright: © 2025 Zhang, Yang, Wang, Hu, Deng and Lan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jialing Hu, Department of Emergency Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, China
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