REVIEW article
Front. Cell. Neurosci.
Sec. Cellular Neurophysiology
Volume 19 - 2025 | doi: 10.3389/fncel.2025.1611370
The SIRT1/AMPK/PGC-1α triad in ischemic stroke: Unveiling neuroprotective strategies
Provisionally accepted
- 1Zhejiang University, Hangzhou, China
- 2Institute of System Medicine, Zhejiang University School of Medicine, Hangzhou, China., hangzhou, China
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The global rise in stroke prevalence presents a major challenge due to limited treatment options and persistent neurological deficits. The intricate and elusive nature of stroke's underlying pathophysiology encompasses various mechanisms, such as oxidative stress, mitochondrial impairment, and neuroinflammation, which continue to challenge our understanding. The SIRT1/AMPK/PGC-1α pathway emerges as a critical mechanism among these, playing a key role in neuronal protection against damage induced by stroke. This review investigates the possible therapeutic advantages of targeting this pathway, specifically examining how flavonoids could offer a promising approach to mitigating complications resulting from stroke. Moving beyond traditional drug-based treatments, researchers are turning their attention to alternative approaches. These include studying the effects of physical activity and caloric restriction, as well as examining the potential benefits of naturally occurring substances. This multifaceted strategy offers promising new avenues for therapeutic development. This comprehensive review aims to disentangle the intricate connections within these pathways, striving to establish a foundation for innovative multi-target therapeutic strategies. By doing so, it endeavors to revitalize hope in the ongoing efforts against ischemic stroke, potentially lessening its profound impact on global health and overall well-being.
Keywords: ischemic stroke, SIRT1, PGC1α, AMPK, calorie restrictions
Received: 14 Apr 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Abbasi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Irum Abbasi, Zhejiang University, Hangzhou, China
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