REVIEW article
Front. Cell. Neurosci.
Sec. Cellular Neuropathology
Volume 19 - 2025 | doi: 10.3389/fncel.2025.1635551
This article is part of the Research TopicOligodendroglia Biology and Pathology: Myelination and BeyondView all 7 articles
Wrap it up: Myelination of transplanted neurons for repair
Provisionally accepted
María Fernanda Martínez-Reza1,2,3*
Magdalena Götz1,2*- 1Ludwig Maximilian University of Munich, Munich, Germany
- 2Institute of Stem Cell Research, Helmholtz Center Munich, Munich, Germany
- 3Graduate School of Systemic Neuroscience (GSN), Ludwig-Maximilians-Universität, Munich, Germany
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Degeneration or damage of neuronal circuits in the central nervous system can lead to an irreversible loss of neurons and function in the affected brain region. Neuronal transplantation is a promising therapeutic approach consisting of introducing healthy cells into the damaged or diseased regions to restore lost circuits. To achieve successful neuronal transplantation, proper integration of the graft in the host circuitry is necessary. This includes the restoration of connectivity as well as the recapitulation of the physiological characteristics of the lost endogenous neurons. An often-overlooked aspect to assess the integration of transplanted neurons is the acquisition of cell-extrinsic features, such as myelination. This review explores the interaction between transplanted cells and endogenous oligodendroglia, the evidence of myelination in different neuronal transplantation models, the checkpoints that can influence graft myelination in the injured or diseased brain and explores how appropriate myelin ensheathment could help overcome some challenges faced in the field of neuronal replacement.
Keywords: neuronal transplantation, Myelination, oligodendrocytes, CNS repair, neuronal graft, Neuronal replacement, neurodegeneration, Stroke
Received: 26 May 2025; Accepted: 18 Sep 2025.
Copyright: © 2025 Martínez-Reza and Götz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
María Fernanda Martínez-Reza, fernanda.mreza@bmc.med.lmu.de
Magdalena Götz, magdalena.goetz@helmholtz-munich.de
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