REVIEW article
Front. Cell. Neurosci.
Sec. Cellular Neuropathology
Volume 19 - 2025 | doi: 10.3389/fncel.2025.1645639
This article is part of the Research TopicTransforming Neurological Recovery: The Promise of Regenerative NeurorehabilitationView all 6 articles
NcRNAs: A Potential Treatment for Spinal Cord Injury
Provisionally accepted
Chunhui Guo*
Jie Bao- Guangxi University of Chinese Medicine, Nanning, China
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Spinal cord injury (SCI) is a serious disorder that affects sensory, motor, and autonomic functions. Its pathological process is divided into two stages: primary and secondary injury. The secondary injury involves a variety of biological cascade reactions, leading to an imbalance in the spinal cord microenvironment. Non-coding RNAs (ncRNAs) play a crucial regulatory role in the pathophysiological process of spinal cord injury, including long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs), all of which are involved in processes such as axonal regeneration, oxidative stress, inflammatory response, autophagy, and apoptosis. Although the pathophysiological process of spinal cord injury has been partially elucidated, its pathogenesis is not yet fully understood, and effective treatments are limited. This article reviews the regulatory role and molecular mechanisms of ncRNAs in the development and progression of spinal cord injury and proposes strategies for treating spinal cord injury by regulating ncRNAs.
Keywords: spinal cord injury, sci, circular RNA, long non-coding RNA, microRNA
Received: 13 Jun 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Guo and Bao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chunhui Guo, Guangxi University of Chinese Medicine, Nanning, China
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