ORIGINAL RESEARCH article
Front. Cell. Neurosci.
Sec. Cellular Neuropathology
This article is part of the Research TopicMechanisms of exercise-induced changes in amyloid precursor protein processingView all 4 articles
Study on the effect of mesenchymal stem cells on neural injury, inflammation and copper content in Wilson Disease
Provisionally accepted
- 1Sun Yat-sen University, Guangzhou, China
- 2Sun Yat-Sen University, Guangzhou, China
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[Abstract] Objective: To investigate the effects of bone marrow mesenchymal stem cells (BMSCs) on extrapyramidal neural network of Wilson disease (WD). Methods: 27 6-month-old toxic milk mice (TX mice, WD animal model) and 15 C57 mice were selected. Corrected phase (CP) value on susceptibility weighted imaging (SWI), fractional anisotropy (FA) on diffusion tensor imaging (DTI) were performed. The volume of fiber connections was determined. BMSCs was transplanted though tail vein injection (1×106, 0.5mL). The myelin basic protein (MBP), amyloid precursor protein (β-APP), nitric oxide (NO), glutathione (GSH) and interleukin (IL-1β) were determined at 1, 2, 4 and 8 weeks after transplantation. Results: The CP value of TX mice increased at 4 (p=0.029) and 8 weeks (p=0.037) after transplantation. FA values (p=0.026, 0.020, 0.037) and the volume of neural fibers (p=0.016, 0.023, 0.018) increased at 2, 4 and 8 weeks after transplantation. The pathological indexes of demyelination (MBP) and axon injury (β-APP) improved after BMSCs transplantation. The brain copper content decreased at 4 and 8 weeks after transplantation (p=0.024, 0.038). The indexes of oxidative stress (NO and GSH) and inflammation (IL-1β) of TX mice were improved after transplantation. Conclusion: BMSCs can ameliorate WD extrapyramidal neural network injury. The mechanism may be related to reducing copper deposition and alleviating oxidative stress and inflammatory response.
Keywords: Wilson disease, Bone marrow mesenchymal stem cells, Extrapyramidal neural network, Oxidative Stress, Magnetic sensitive imaging, Copper metabolism
Received: 16 Jun 2025; Accepted: 29 Oct 2025.
Copyright: © 2025 Zhou, Qin, Chen, Liao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiangxue Zhou, zxx7317@163.com
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