Invited ms for the collection "Reviews in Cellular Neurophysiology 2025", edited by Luca Raiteri, Giuseppe

Elena NigiYang Jenq-weiHeiko J. Luhmann^*Anne Sinning

• Universitatsmedizin der Johannes Gutenberg-Universitat Mainz Institut fur Physiologie, Mainz, Germany

Neuronal activity in the cerebral cortex comes in surprisingly early and influences or even controls a number of important developmental process like neurogenesis, neuronal migration, myelination, formation of cortical maps and local circuits, and programmed cell death. During the late prenatal and early postnatal period, the neocortical network shows a developmental transition from sparse, synchronized, low activity patterns to continuous, desynchronized, high activity patterns. This developmental sequence has been demonstrated in various neocortical areas of different mammalian species. This review article aims to provide a comprehensive overview of the early development of neuronal network activity in the cerebral cortex. We mainly focus on the rodent barrel cortex and a developmental period when the cortex gains mature functional properties at the cellular and network level. After briefly summarizing the developmental processes underlying the construction, reconstruction and deconstruction of neocortical circuits, we describe the agedependent changes in spontaneous and sensory driven network activity. Next we discuss the functional role of transient cortical structures and cell types in the generation of early activity patterns and in the activity-dependent maturation of local and large-scale cortical networks. Finally, we present an outlook on the models and techniques to study the cellular and network mechanisms underlying neuronal activity in the developing cerebral cortex.