REVIEW article
Front. Cell. Neurosci.
Sec. Cellular Neuropathology
This article is part of the Research TopicIntercellular communication in chronic neuroinflammatory diseasesView all 6 articles
Astrocytic and microglial cell functions in neuroinflammatory diseases and their animal models
Provisionally accepted
- 1Ochanomizu Joshi Daigaku, Bunkyo, Japan
- 2Teikyo Daigaku, Itabashi, Japan
- 3Kitasato University School of Frontier Engineering, Kanagawa, Japan
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Neurodegenerative diseases are frequently accompanied by inflammatory responses and alterations in lipid metabolism, both of which are believed to negatively affect neural regeneration in mammals. In addition to immune cells, glial cells such as astrocytes and microglia contribute significantly to these inflammatory processes, and it is now recognized that lipid droplet accumulation and cholesterol metabolism are dysregulated in these glial cells. Consequently, recent studies have examined inflammation and lipid metabolism from the standpoint of glial cell function; however, effective therapeutic strategies remain unestablished. By contrast, in zebrafish, a teleost species, robust neural regeneration occurs within a short period after injury to the telencephalon or spinal cord. In this review, we aimed to identify candidate functional factors by comparing mouse and zebrafish disease models and to explore molecules with potential therapeutic relevance for mammalian neurological disorders.
Keywords: Alzheimer's disease, astrocyte, lipid droplet, Microglia, Mouse, Parkinson's disease, TBI, Zebrafish
Received: 19 Sep 2025; Accepted: 17 Nov 2025.
Copyright: © 2025 HASHIMOTO, GOTOH and Ikeshima-Kataoka. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hiroko Ikeshima-Kataoka, ikeshima.hiroko@kitasato-u.ac.jp
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.