REVIEW article
Front. Cell. Neurosci.
Sec. Non-Neuronal Cells
Advances in Astrocytic Calcium Signaling Research
Provisionally accepted
- 1Qinghai University School of Medicine, Xining, China
- 2Gansu University of Chinese Medicine, Lanzhou, China
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Astrocytes are the most abundant glial cells in the central nervous system. They detect neuronal activity through Ca2+ signals and thereby regulate synaptic plasticity, integrate neuronal information, and maintain extracellular homeostasis. Growing evidence indicates that aberrant astrocytic Ca2+ signaling is an important pathological factor in the onset and progression of many neurological disorders. In this review, we systematically summarize the sources, classifications, detection methods, and functional significance of astrocyte Ca2+ signaling, with the aim of improving understanding of astrocyte function and providing new perspectives and rationale for therapeutic strategies targeting related diseases.
Keywords: astrocyte calcium signaling, review, astrocyte, Calcium, Calcium Signaling
Received: 07 Oct 2025; Accepted: 05 Nov 2025.
Copyright: © 2025 Chen, Ye, Jia, Long, Dou and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xingke Yan, xxxbbb2028@163.com
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