ORIGINAL RESEARCH article
Front. Comput. Neurosci.
Volume 19 - 2025 | doi: 10.3389/fncom.2025.1591003
This article is part of the Research TopicRealistic Multi-Scale Modeling of Neural Circuit DynamicsView all articles
Regulation of sharp wave-ripples by cholecystokinin-expressing interneurons and parvalbumin-expressing basket cells in the hippocampal CA3 region
Provisionally accepted
- 1School of Science, Beijing University of Posts and Telecommunications (BUPT), Beijing, Beijing Municipality, China
- 2Key Laboratory of Mathematics and Information Networks (Beijing University of Posts and Telecommunications), Ministry of Education, Beijing, China
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To explore the individual and interactive effects of the interneurons cholecystokinin-expressing interneurons (CCKs) and parvalbumin-expressing basket cells (BCs) on sharp wave-ripples (SWR) and the underlying mechanisms, we constructed a mathematical model of the hippocampal CA3 network. By modulating the activity of CCKs and BCs, it was verified that CCKs inhibit the generation of SWR, while the activity of BCs affects the occurrence of SWR. Additionally, it was postulated that CCKs exert an influence on SWR through a direct mechanism, wherein CCKs directly modulate pyramidal cells (PCs). It was also discovered that BCs control SWR mainly through mutual inhibition among BCs. Furthermore, by adjusting the strength of the interaction between BCs and CCKs at various levels, it was identified that the interaction between these two types of interneurons has a relatively symmetrical effect on the regulation of SWR, functioning through a mutual inhibition mechanism. Our findings not only offer a deeper understanding of how CCKs and BCs independently regulate the generation of SWR but also provide novel insights into how changes in the strength of their interaction affect network oscillations. The results emphasize the crucial role of inhibitory interneurons in maintaining normal hippocampal oscillations, which are essential for proper brain function, particularly in the domains of memory consolidation and cognitive processes.
Keywords: Sharp wave-ripples, Interneurons, mutual inhibition, CA3, Hippocampus
Received: 10 Mar 2025; Accepted: 05 May 2025.
Copyright: © 2025 Yang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaojuan Sun, School of Science, Beijing University of Posts and Telecommunications (BUPT), Beijing, 100876, Beijing Municipality, China
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