EDITORIAL article
Front. Comput. Neurosci.
Volume 19 - 2025 | doi: 10.3389/fncom.2025.1664088
This article is part of the Research TopicCardio-Respiratory-Brain Integrative Physiology: Interactions, Mechanisms, and Methods for AssessmentView all 12 articles
Editorial: Cardio-Respiratory-Brain Integrative Physiology: Interactions, Mechanisms, and Methods for Assessment
Provisionally accepted
- 1Univerzitet u Beogradu Institut za nuklearne nauke Vinca, Belgrade, Serbia
- 2Universita degli Studi di Palermo, Palermo, Italy
- 3Univerzitet u Novom Sadu Fakultet tehnickih nauka, Novi Sad, Serbia
- 4Humboldt-Universitat zu Berlin, Berlin, Germany
- 5Saints Cyril and Methodius University of Skopje, Skopje, North Macedonia
- 6Department of Physics, Lancaster University, Lancaster, UK, Lancaster, United Kingdom
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The discipline of cardio-respiratory-brain integrative physiology investigates the complex interactions among the heart, lungs, and brain, emphasizing how these systems work together to sustain overall stability and balance within the body. The cardiorespiratory coupling was studied in some recent studies (Schulz et al. (2013); Acampa et al. (2021); Kapidžić et al. (2014)), including the respiratory sinus arrhythmia (Hirsch and Bishop (1981)), cardiorespiratory phase synchronization (Schäfer et al. (1998)) and coupling functions (Iatsenko (Bernjak); Lukarski et al. (2020)). These coupling forms are primarily regulated by the brain, which is the core node of the well-known functional brain-heart interplay Candia-Rivera et al. (2025) and mediates interactions with the lungs through the respiratory centers Faes et al. (2015); Stankovski et al. (2016) (Fig. 1). Interactions among the cardiac, respiratory, and brain systems are essential for understanding the central-autonomic network, which regulates the balance between parasympathetic and sympathetic nervous activity to adapt to different physiological and environmental challenges. Although progress has been made, gaps still exist in fully understanding the exact mechanisms and pathways driving these interactions, especially in disease states where imbalances can result in negative health effects. Recent research efforts are increasingly employing sophisticated signal processing and neuroimaging methods 1. Physiological network for the brain-heart-lungs interactions.to explore these complex dynamics, but a complete understanding of the integrated physiology of these 20 systems is still evolving. The research topic aim was to enhance the understanding of cardio-respiratory-brain interactions by
Keywords: Brain, Heart, lungs, interactions, Physiology, mechanisms, networks, methods
Received: 11 Jul 2025; Accepted: 22 Jul 2025.
Copyright: © 2025 Bojić, Faes, Schulz and Stankovski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tomislav Stankovski, Saints Cyril and Methodius University of Skopje, Skopje, North Macedonia
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