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ORIGINAL RESEARCH article

Front. Digit. Health

Sec. Health Technology Implementation

Volume 7 - 2025 | doi: 10.3389/fdgth.2025.1478688

This article is part of the Research TopicApplication of Deep Learning in Biomedical Image ProcessingView all 9 articles

Skin Disease Diagnosis using Decision and Feature Level Fusion of Deep Features

Provisionally accepted
Md. Zasim  UddinMd. Zasim Uddin1*Md. Arif  ShahriarMd. Arif Shahriar1Björn W.  SchullerBjörn W. Schuller2,3*Md. Nadim  MahamoodMd. Nadim Mahamood1Md Atiqur Rahman  AhadMd Atiqur Rahman Ahad4
  • 1Begum Rokeya University, Rangpur City, Bangladesh
  • 2Universitätsbibliothek, Technische Universität München, Munich, Bavaria, Germany
  • 3Imperial College London, London, England, United Kingdom
  • 4University of East London, London, United Kingdom

The final, formatted version of the article will be published soon.

Early skin disease diagnosis is essential and one of the challenging tasks for a dermatologist. Manual diagnosis by healthcare providers is subjective, costly, and may yield inconsistent results. In contrast, automated skin disease detection and classification using traditional machine learning and deep learning approaches have shown promise in addressing this problem. In this study, we propose a hybrid ensemble framework that integrates both feature-level fusion (FLF) and decision-level fusion (DLF) to leverage complementary strengths for detecting and classifying skin diseases. We employ two convolutional neural network (CNN)-based models, i.e., a modified DenseNet201 and VGG19, along with an attention-based model vision transformer (ViT) to identify and classify skin diseases. In FLF, feature representations from these models are point-wise added and passed through a shared classification head to make the final prediction. In DLF, decisions from each base model are collected, and the majority voting scheme is used to make a final decision. Furthermore, we incorporate a generative adversarial network (GAN)-based approach for offline-based training data augmentation to reduce overfitting and improve performance. Based on different evaluation metrics (i.e., accuracy, precision, recall, and F1-score), our proposed framework demonstrates superior performance on four benchmark datasets: the PH2, HAM10000, ISIC 2018, and ISIC 2019 datasets, with an accuracy of 99.3\%/99.2\%, 92.7\%/96.1\%, 86.7\%/89.0\%, and 94.5\%/95.0\%, respectively, for FLF/DLF. These results demonstrate that while both fusion strategies are effective, DLF slightly outperforms FLF, emphasizing the value of ensemble decision aggregation for robust skin disease classification.

Keywords: skin disease diagnosis, deep learning, Feature-level fusion, Decision-Level Fusion, GaN, Classification

Received: 10 Aug 2024; Accepted: 25 Sep 2025.

Copyright: © 2025 Uddin, Shahriar, Schuller, Mahamood and Ahad. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Md. Zasim Uddin, zasim@brur.ac.bd
Björn W. Schuller, schuller@tum.de

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