REVIEW article
Front. Genet.
Sec. Epigenomics and Epigenetics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1526852
This article is part of the Research TopicProtein Modifications in Epigenetic Dysfunctional Diseases: Mechanisms and Potential Therapeutic Strategies, Volume IIView all articles
Recent advances of DNA methylation in osteonecrosis of the femoral head
Provisionally accepted
- 1Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
- 2Hebei University of Chinese Medicine, Shijiazhuang, Hebei Province, China
- 3Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Municipality, China
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DNA methylation, maintenance, and demethylation are essential for maintaining normal physiological functions. Recent studies have revealed that DNA methylation plays a crucial role in the progression of osteonecrosis of the femoral head. DNA methylation regulates the differentiation direction of bone marrow mesenchymal stem cells, affects angiogenesis, and is involved in the proliferation and apoptosis of osteocytes, holding significant potential for early diagnosis and treatment of the disease. This paper introduces the concept and process of DNA methylation, with an emphasis on its molecular mechanisms in osteonecrosis of the femoral head. Furthermore, we propose that modulating different states of DNA methylation, such as inhibiting the function of DNA methyltransferases to induce DNA demethylation, could impact the disease progression of osteonecrosis of the femoral head, offering new insights for its treatment.
Keywords: Osteonecrosis of the femoral head, DNA Methylation, osteoblast differentiation, Angiogenesis, Osteocyte apoptosis
Received: 12 Nov 2024; Accepted: 09 Sep 2025.
Copyright: © 2025 ZHOU, LIU, LI, Zhang and LI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoming LI, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
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