ORIGINAL RESEARCH article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1543593
Constructing a novel mitochondrial-related gene signature for predicting survival and evaluating the tumor immune microenvironment in clear cell renal cell carcinoma
Provisionally accepted
- First Affiliated Hospital of Xiamen University, Xiamen, China
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Background: Cellular energy supply, signaling, metabolism, autophagy, aging, and tumorigenesis are all associated with mitochondria. Mitochondria plays an important role in tumors. However, we lack a reliable prognostic model in clear cell renal cell carcinoma (ccRCC) according to mitochondrial-related genes. Methods: A systematic analysis of available TCGA databases and related studies was conducted by R language and online analysis tools to evaluate the prognostic value of mitochondrial-related genes and the tumor microenvironment in ccRCC. Results: We constructed a novel mitochondrial-related gene signature for predicting survival and evaluating the tumor immune microenvironment in ccRCC. The mitochondrial-related gene signature included MICALL2, FKBP10 and ACADSB. According to the risk score of the risk model, ccRCC patients were divided into high risk group or low risk group. The ccRCC high risk group with high risk score is related to poor prognosis, and related to poor efficacy from immune checkpoint inhibitors (ICIs). Conclusions: Our mitochondrial-related gene signature, as a risk model, could be a reliable ccRCC prognostic biomarker and could predict the response to immunotherapy. The risk score was correlated to the tumor microenvironment and immune cell infiltration.
Keywords: mitochondrial-related gene, Survival, Tumor immune microenvironment, Clear cell renal cell carcinoma, bioinformatics
Received: 11 Dec 2024; Accepted: 01 Sep 2025.
Copyright: © 2025 Qin, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiaxuan Qin, First Affiliated Hospital of Xiamen University, Xiamen, China
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