ORIGINAL RESEARCH article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1556366
This article is part of the Research TopicCancer Cell Metabolism and Tumor Microenvironment RemodelView all 4 articles
Comprehensive bioinformatics analysis of malignant transformation and potential therapeutic possibility of lung adenocarcinoma after lipopolysaccharide induction
Provisionally accepted
- 1Bengbu Medical College, Bengbu, China
- 2Xi'an Fifth Hospital, Xi'an, Shaanxi, China
- 3Bengbu First People's Hospital, Bengbu, Anhui Province, China
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Background: Lipopolysaccharides are involved in malignant progression and epithelial-mesenchymal transition of cancer. The mechanism of LPS in malignant progression of lung adenocarcinoma and possible therapeutic strategies need to be explored. Methods: After obtaining LPS-induced characteristics, 850 samples were characterized. Differences in features were evaluated in different risk subgroups. Cell lines with high scoring performance were selected for in vitro experimental validation and possible potential therapeutic options were identified. Results: By using bioinformatics analysis to obtain LPS signature genes from the LPS induction cohort, the five intersecting genes were utilized to construct a risk model associated with LPS induction. The high-risk score subgroup had a poorer prognosis and lower immunotherapy response, and this subgroup showed distinct EMT features such as hypoxia pathway, high enrichment of WNT pathway and high TP53 mutation. After verifying that the risk model has a close correlation with EMT progression, we obtained cell lines with high EMT-associated features, confirming the possibility of LPS-induced EMT, i.e., demonstrating that LPS acts in inducing EMT progression. The malignant progression of tumors could be inhibited using rosiglitazone and liraglutide combined with lipid-forming trans-differentiation therapy. Conclusion: In the field of bioinformatics, our study acquired genes characteristic of lipopolysaccharide-induced lung adenocarcinomas and elucidated for the first time that LPS-induced associated scoring patterns correlate with EMT progression. In addition, we propose the possibility of treatment with trans-differentiation therapies that utilize the high plasticity that EMT progressing cancer cells have.
Keywords: Lung Adenocarcinoma, bioinformatics, lipopolysaccharide, trans-differentiation therapy, adipogenic, Epithelial-Mesenchymal Transition
Received: 06 Jan 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Wanjie, Zhang, Zhang, Wang, Xie, Min, Wang and Lian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chaoqun Lian, Bengbu Medical College, Bengbu, China
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