REVIEW article
Front. Genet.
Sec. Genetics of Aging
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1559510
This article is part of the Research TopicGenetics (SKINOMICS): New Trends in Skin Aging Research and Clinical ApplicationView all 3 articles
Genetic Profiling and Precision Skin Care: A Review
Provisionally accepted
- 1Nomige, Gent, Belgium
- 2Centre Médical Laser Palaiseau, Palaiseau, France., Paris, France
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Skin aging is a multifaceted biological phenomenon driven by intrinsic and extrinsic factors, including genetics, hormonal changes, metabolic shifts, and environmental influences. Notably, genetic factors play a significant role, explaining up to 60% of the variability in how individuals age. Genes such as elastin (ELN), filaggrin (FLG), and melanocortin 1 receptor (MC1R) play pivotal roles in processes like elasticity, hydration, and pigmentation, directly impacting both intrinsic and extrinsic aging pathways. Understanding these genetic mechanisms is crucial for advancing personalized anti-aging products and therapies, particularly given the significant variability among individuals and ethnic groups. This review explores the current state of knowledge regarding the genetic determinants of skin aging, highlighting recent discoveries and proposing functional pathways for targeted interventions. Future directions are discussed to highlight the transformative potential of these innovations in clinical and aesthetic dermatology. While genetic factors may account for up to 60% of skin aging variability in specific populations, this figure should be interpreted with caution. It primarily reflects heritability under controlled conditions and does not negate the significant influence of modifiable lifestyle and environmental factors on skin and overall aging.
Keywords: Dermagenetics, genetic profiling, multi-omics, precision dermatology, Skin Aging
Received: 12 Jan 2025; Accepted: 26 May 2025.
Copyright: © 2025 Geusens and HAYKAL. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Barbara Geusens, Nomige, Gent, Belgium
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