BRIEF RESEARCH REPORT article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1569403
Filaggrin High Melanomas Exhibit Active FGFR, and Allergic Signatures, with Impaired GNA14, and Th1 Signatures
Provisionally accepted
Goodwin G Jinesh1*
Isha Godwin2- 1Moffitt Cancer Center, Tampa, United States
- 2Saveetha Medical College, Chennai, Tamil Nadu, India
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Filaggrin gene (FLG/FLG2) product deregulations are associated with various allergic skin diseases including but not limited to atopic dermatitis, alopecia areata, and ichthyosis vulgaris. However, the molecular immunological underpinnings of filaggrin phenotype manifestations are not completely understood. To gain insight on the underlying context, we classified the melanomas based on filaggrin expression (filaggrin High/Low ) and profile the signaling context behind pruritic melanomas. We identify that the major signaling context change behind filaggrin High melanomas are active FGFR signaling, and impaired GNA14 and Th1 signatures in addition to many genetic and immune changes that are associated with pruritis.
Keywords: Filaggrin (FLG), Pruritus, GNA14, IFN-gamma, Th1 signaling, Staphycoccus aureus, Human Papilloma Virus
Received: 08 Feb 2025; Accepted: 27 Jun 2025.
Copyright: © 2025 Jinesh and Godwin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Goodwin G Jinesh, Moffitt Cancer Center, Tampa, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.