ORIGINAL RESEARCH article
Front. Genet.
Sec. Evolutionary and Population Genetics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1580806
Genome-wide association study of cocoon-producing traits in four Henan silkworm strains revealed new candidate genes
Provisionally accepted
- 1Northwest A&F University, Xianyang, China
- 2Henan Agricultural Society, henan, China
- 3Henan Academy of Sericulture Science, Zhengzhou, Henan Province, China
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The silkworm (Bombyx mori), has been farmed in China for over 5,000 years, and holds significant economic value. Recent genomic advances have deepened our understanding of silk production mechanisms, enabling the development of improved silkworm breeds. Further research is needed to identify effective molecular markers linked to silk production traits, as this will enhance genetic improvement efforts.In the genome-wide association analysis study, we identified 40 significant single nucleotide polymorphisms (SNPs) and 28 candidate genes which were related to cocoon shell weight, cocoon width and whole cocoon weight in four silkworm strains in Henan. Through linkage imbalance block analysis, we found that the KWMTBOMO02490 (ATPase inhibitor-like protein) and KWMTBOMO12678 (OTU domain-containing protein 7B) were strongly selected. By using online databases, we found that the KWMTBOMO02490 gene was highly expressed in the posterior silk glands and may play an important role in the process of silk production.The candidate genes in this study may affect the production and health traits of silkworms, and may provide an important reference for silkworm breeding.
Keywords: Genome-Wide Association Study, cocoon-producing traits, Henan silkworm strains, candidate genes, KWMTBOMO02490
Received: 21 Feb 2025; Accepted: 28 May 2025.
Copyright: © 2025 Song, Lyu, Zhang, Ding, Huang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shang Yang, Henan Academy of Sericulture Science, Zhengzhou, Henan Province, China
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