Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic Aluminum workers

YOUXING LI¹Yaqin Pang¹Dongshun Chen¹Feiyu Lu¹Hongyan Tian¹Fengni Qin¹Kuntao Wei¹Ahmad Razali Bin Ishak²Mohd Shukri Bin Mohd Aris^2*Guangzi Qi^1*

• ¹Youjiang Medical University for Nationalities, Baise, China
• ²Universiti Teknologi MARA Puncak Alam, Selangor, Selangor, Malaysia

Background: Various occupational hazards in the electrolytic aluminum environment have been linked to cognitive decline. However, the interactive effects of these hazards and genetic factors on cognitive function remain unclear.Objective: This study aimed to identify the primary occupational hazards, examine their interaction with IL-1β gene polymorphisms in relation to cognitive function.: A cross-sectional study was conducted in June 2024 at an electrolytic aluminum company in China, involving 478 male workers. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). Calculate the cumulative exposure dose (CED) of harmful factors such as aluminum dust. Additionally, IL-1βgene polymorphisms (rs1143627, rs1143643, rs16944, rs3917356) and serum protein levels were analyzed. The associations between environmental exposure, genetic factors, and cognitive function were examined using multivariate stepwise linear regression, restricted cubic splines, generalized linear models, and hierarchical analysis. Covariance analysis and independent sample t-tests were employed to assess the potential mediating effect of peripheral blood IL-1β levels.Results: Cumulative exposure to aluminum dust was significantly associated with cognitive decline (β=-0.18, 95% CI: -0.27, -0.10), and the relationship was linear.Compared to the wild genotype, individuals carrying rs1143627 G/G, rs1143643 C/C, and rs16944 A/A exhibited significantly lower cognitive scores (P<0.01), whereas rs3917356 C/T and T/T conferred a protective effect (P<0.01). The model was adjusted for age, BMI, and cumulative aluminum dust exposure. The genetic effect associated with IL-1β was more pronounced in individuals with high aluminum exposure (>2.37 mg/m³×year). IL-1β serum protein levels showed no significant association with cognitive function (P>0.05).Cumulative exposure to aluminum dust is a key risk factor for cognitive decline. IL-1β polymorphisms influence susceptibility, with the effect becoming more pronounced under high aluminum exposure. However, peripheral blood IL-1β levels do not mediate this association with cognitive decline.