ORIGINAL RESEARCH article
Front. Genet.
Sec. Applied Genetic Epidemiology
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1593728
This article is part of the Research TopicInborn Errors of Carbohydrate Metabolism Volume IIView all 4 articles
Global, Regional, and National Burden of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency from 1990 to 2021: A Systematic Analysis of the Global Burden of Disease Study 2021
Provisionally accepted
- 1West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China
- 2National Center For Occupational Safety And Health NHC, Beijing, China
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Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency remains a significant global health burden, particularly in malaria-endemic regions. Despite advances in diagnostic capabilities and treatment strategies, the prevalence and associated disability burden continue to evolve. This study provides a comprehensive assessment of the global, regional, and national burden of G6PD deficiency from 1990 to 2021, using the Global Burden of Disease (GBD) 2021 database.Methods: Data were retrieved from GBD 2021, covering 204 countries and territories. Prevalence, incidence, and years lived with disability (YLDs) were analyzed. Age-standardized rates (ASRs) and estimated annual percentage change (EAPC) were computed to assess trends over time. The relationship between socio-demographic index (SDI) and G6PD burden was examined using Spearman correlation analysis.In 2021, global prevalence reached 443,326,869 cases, an 80.17% increase from 1990.The highest burden was observed in South Asia, accounting for 138,159,940 cases. The largest percentage increase in prevalence was in Andean Latin America (+291.96%). G6PD deficiency burden was negatively correlated with SDI, but high SDI regions exhibited higher prevalence than expected. Ageand sex-specific analysis revealed a higher burden in males, particularly in childhood and older age groups.This study underscores the growing burden of G6PD deficiency, with substantial regional disparities. The findings emphasize the need for improved screening programs, policy interventions, and resource allocation in low-and middle-income countries (LMICs). Continued surveillance is essential to mitigate the long-term health consequences of this disorder.
Keywords: Glucose 6-phosphate dehydrogenase deficiency, Global burden of disease, Prevalence, Years lived with disability, Epidemiology
Received: 20 Mar 2025; Accepted: 12 May 2025.
Copyright: © 2025 Yu, Xioing, Wang, Li and Niu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ting Niu, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China
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