REVIEW article
Front. Genet.
Sec. Human and Medical Genomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1597287
This article is part of the Research TopicGenomic Insights into Reproductive Regulation: Advances in Male and Female Fertility MechanismsView all 5 articles
Leveraging epigenetic aberrations in the pathogenesis of endometriosis: From DNA methylation to non-coding RNAs
Provisionally accepted
- 1Immunopathology-Immunomonitoring-Immunotherapy Laboratory, Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
- 2Laboratory of Medical Analysis and Reproductive Biology, Labomac, Casablanca, Morocco
- 3Mediterranean Center for Molecular Medicine C3M, Nice, France
- 4Department of Obstetrics and Gynecology, Les Iris Clinic, Casablanca, Morocco
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Endometriosis is highly underdiagnosed and undertreated gynecological disorder, with diagnosis often delayed by 8 to 12 years. This delay can have serious consequences including infertility. Currently, the gold standard for endometriosis diagnosis and treatment is laparoscopy, an invasive surgical intervention. The molecular mechanisms underlying the onset of endometriosis are yet unclear, but it is assumed that epigenetic modifications are an important contributor in the etiopathology of the disease. Given that, dissecting the features of epigenetic aberrations underlying endometriosis can be a crucial step toward developing early and accurate non-invasive diagnostic tools. Accurate and timely diagnosis of endometriosis can significantly reduce healthcare costs, and enhance women's social wellbeing. Epigenetic modifications especially DNA methylation, micro-RNAs and long-RNAs, hold promise as potential biomarkers for the early diagnosis of endometriosis. This review underscores the innovative potential of epigenetic mechanisms as early biomarkers for endometriosis diagnosis. We summarize and critically discuss recent findings and epigenetic modifications role in endometriosis pathophysiology, from DNA methylation and histone modifications to non-coding RNAs in different tissues.
Keywords: Endometriosis, epigenetic modifications, DNA Methylation, Histone Modifications, non-coding RNAs, micro-RNAs, long-RNAs, Infertility
Received: 20 Mar 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 ERRAJI, Ghanmi, Louanjli, Benahmed, Zarqaoui and GHAZI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bouchra GHAZI, Immunopathology-Immunomonitoring-Immunotherapy Laboratory, Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco
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