ORIGINAL RESEARCH article
Front. Genet.
Sec. Computational Genomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1607446
A bioinformatics analysis on the correlation between hepatic ischemiareperfusion injury and postoperative cognitive dysfunction
Provisionally accepted
- 承德医学院附属医院, Chengde, Hebei, China, China
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BACKGROUND: Postoperative cognitive dysfunction (POCD)is a common postoperative complication that is prevalent in older people. More and more elderly patients are undergoing surgery. As a result, the number of patients presenting with POCD is increasing. Previous studies have demonstrated that hepatic ischemia-reperfusion injury(HIRI)in mice is associated with postoperative cognitive impairment. T herefore, this study investigated the relationship between POCD and HIRI using bioinformatics research methods.• METHODS: The GEO database GSE202565 and GeneCard data were selected for correlation analysis using bioinformatic analysis methods. The GEO database dataset GSE112713 was chosen for preliminary validation of the screened Hub genes.• RESULTS: We analyzed the dataset GSE202565 for differences in gene expression before and after hepatic postischemic reperfusion and obtained a total of 53 genes by identifying POCDrelated genes. We also screened these 53 genes again and obtained 10 Hub genes, which were analyzed and correlation predicted. Finally, these 10 Hub genes were partially preliminarily validated by the dataset GSE112713.• CONCLUSION: HIRI is closely related to POCD, and reducing the occurrence of HIRI may become one of the ways to avoid or improve postoperative cognitive impairment in the future.
Keywords: Liver ischemia-reperfusion injury, postoperative cognitive dysfunction, Bioinformatics analysis, drug-gene interaction prediction, MiRNA prediction
Received: 08 Apr 2025; Accepted: 24 Jun 2025.
Copyright: © 2025 Hu, Liu, Bao, Feng, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianling Li, 承德医学院附属医院, Chengde, Hebei, China, China
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